March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Retinal Blood Flow In Proliferative Diabetic Retinopathy By Fourier-domain Optical Coherence Tomography: Measurements Before And After Panretinal Photocoagulation
Author Affiliations & Notes
  • Jennifer C. lee
    Ophthalmology, Doheny Eye Institute - USC, Los Angeles, California
  • Brandon Wong
    Ophthalmology, Doheny Eye Institute - USC, Los Angeles, California
  • Elnaz Rakhshan
    Ophthalmology, Doheny Eye Institute - USC, Los Angeles, California
  • Ou Tan
    Ophthalmology,
    Oregon Health & Science Univ, Portland, Oregon
  • Srinivas R. Sadda
    Ophthalmology, Doheny Eye Institute - USC, Los Angeles, California
  • David Huang
    Casey Eye Institute,
    Oregon Health & Science Univ, Portland, Oregon
  • Amani A. Fawzi
    Ophthalmology-Univ of Southern Cal, Doheny Eye Institute, Los Angeles, California
  • Footnotes
    Commercial Relationships  Jennifer C. lee, None; Brandon Wong, None; Elnaz Rakhshan, None; Ou Tan, Optovue (P); Srinivas R. Sadda, Carl Zeiss Meditec, Optovue, Inc. (F), Heidelberg Engineering (C), Topcon Medical System (P); David Huang, Carl Zeiss Meditec, Inc. (P), Optovue, Inc. (F, I, C, P, R); Amani A. Fawzi, None
  • Footnotes
    Support  NIH Grant R01-EY013516 (Huang PI)
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2154. doi:
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      Jennifer C. lee, Brandon Wong, Elnaz Rakhshan, Ou Tan, Srinivas R. Sadda, David Huang, Amani A. Fawzi; Retinal Blood Flow In Proliferative Diabetic Retinopathy By Fourier-domain Optical Coherence Tomography: Measurements Before And After Panretinal Photocoagulation. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2154.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

The purpose of this study is to determine retinal venous blood flow in proliferative diabetic retinopathy(PDR) as compared to normal eyes using Doppler Fourier-domain optical coherence tomography(FD-OCT), and to determine the effect of panretinal photocoagulation(PRP) on retinal blood flow.

 
Methods:
 

This is a prospective interventional pilot study. Inclusion criteria were a clinical diagnosis of PDR without prior PRP or vitreous hemorrhage. Double circular Doppler scans of peripapillary blood vessels were performed using the RTVue FD-OCT system (Optovue Inc., Fremont, CA, USA). Retinal blood flow was measured according to a previously described method where candidate vessels are chosen by computer algorithms and in post-processing the reader manually refines the results. Total retinal blood flow was measured by summing the flow from all detectable veins. Pre-PRP Doppler FD-OCT scans were analyzed for all PDR subjects (6), and post-PRP Doppler FD-OCT scans were analyzed on four of them at the time of submission.

 
Results:
 

Blood flow at baseline was not significantly different between PDR and control eyes (p=0.86), however, post-PRP there was a trend for decreasing blood flow in PDR (p=0.06). Compared to controls, PDR eyes had statistically significant decrease in venous velocity at baseline (p=0.01) and post- PRP laser (p=0.01), along with statistically non-significant increased venous caliber (p=0.15) (Table 1).

 
Conclusions:
 

Retinal venous velocity is slower in PDR eyes compared to normal eyes. There is a trend towards decreased total retinal blood flow in the early 7-8 weeks post-PRP period. Additional patients and sequential post-PRP follow-up are ongoing to further characterize the retinal vascular effects of PDR and PRP treatment.  

 
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • diabetic retinopathy 
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