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Olof B. Olafsdottir, Thorunn S. Eliasdottir, Jona V. Kristjansdottir, Sveinn H. Hardarson, Einar Stefánsson; Retinal Oxygen Saturation during Hyperoxia in Healthy Individuals. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2166.
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To detect whether hyperoxia affects oxygen saturation in retinal arterioles and venules in healthy individuals. To test the sensitivity of a retinal oximeter.
Retinal vessel oxygen saturation was measured in 31 healthy individuals with a spectrophotometric retinal oximeter (Oxymap ehf., Reykjavik, Iceland). Oximetry was performed during breathing of room air, during breathing of 100% O2 (10 minutes, 6L/min) and then again during breathing of room air (10 minutes recovery). Statistical analysis was performed with Student’s t-test for paired measurements.
The retinal oximeter measures stable baselines and is sensitive to changes in O2 saturation and vessel diameter. Breathing 100% O2 increases oxygen saturation in retinal arterioles and venules and constricts them compared to normoxic levels.
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