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Gisli H. Halldorsson, Robert A. Karlsson, Einar Stefánsson; Scanning Laser Oximetry: A New Approach To Metabolic Imaging Of The Retina. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2199.
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To develop and test a system for retinal oximetry based on scanning laser ophthalmoscopy (SLO).
The system successfully produced pseudocolor images showing oxygen saturation in retinal arterioles and venules (figure). In one eye mean retinal arteriolar oxygen saturation was 95% and the mean venular oxygen saturation was 66%. In another individual mean arteriolar oxygen saturation was measured 107% and the venular mean was 55%.
It is technically possible to derive information on retinal vessel oxygen saturation from a scanning laser ophthalmoscope with two wavelength oximetry algorithm. Preliminary results are promising and suggest that scanning laser ophthalmoscopy may be used for retinal oximetry.
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