March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Prospective Evaluation of Retinal Microvascular Parametric Changes in Patients with HIV
Author Affiliations & Notes
  • Petrina Tan
    Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore
  • Owen K. Hee
    Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore
  • Carol Y. Cheung
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • Tun Kuan Yeo
    Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore
  • Rupesh Agrawal
    Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore
  • James Ng
    Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore
  • Claire Han
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
  • Tock H. Lim
    Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore
  • Tien Y. Wong
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • Stephen C. Teoh
    Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore
  • Footnotes
    Commercial Relationships  Petrina Tan, None; Owen K. Hee, None; Carol Y. Cheung, None; Tun Kuan Yeo, None; Rupesh Agrawal, None; James Ng, None; Claire Han, None; Tock H. Lim, Novartis, Heidelberg Engineering (R); Tien Y. Wong, None; Stephen C. Teoh, None
  • Footnotes
    Support  National Healthcare Group Small Innovative Grant
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2657. doi:
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      Petrina Tan, Owen K. Hee, Carol Y. Cheung, Tun Kuan Yeo, Rupesh Agrawal, James Ng, Claire Han, Tock H. Lim, Tien Y. Wong, Stephen C. Teoh; Prospective Evaluation of Retinal Microvascular Parametric Changes in Patients with HIV. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2657.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To measure and compare retinal vascular parameters between patients infected with Human Immunodeficiency Virus (HIV) and controls, and to elicit the relationship between retinal vascular parameters and CD4 counts.

 
Methods:
 

Prospective observational case-control study. 37 HIV patients with no clinical retinal pathology and 111 age-gender matched normal healthy controls from Singapore population-based studies were recruited. Standard retinal photographs were taken centered around the optic disc. Quantitative retinal vascular parameters (retinal vascular caliber, branching angle, tortuosity and fractal dimension) were measured from the photographs using a semi-automated computer-based program (Singapore I Vessel Assessment, version 3.0) by trained technicians following a standardized protocol.

 
Results:
 

Patients with HIV were more likely to have higher total fractal dimension (1.457 vs. 1.439, p=0.045), higher venular fractal dimension (1.246 vs. 1.218, p=0.004), more tortuous arterioles (0.741 vs. 0.560 [x105], p<0.001) and venules (0.883 vs. 0.717 [x105], p<0.001), compared with healthy normal subjects. Amongst the HIV patients, decreased CD4 counts was independently associated with narrower retinal arteriolar caliber (β=0.060, p=0.006), after adjusting for age, gender, duration of HIV, hypertension and diabetes.

 
Conclusions:
 

HIV is associated with unique retinal microvascular parametric changes. A linear relationship between CD4 counts and retinal vascular parameters is present.  

 
Clinical Trial:
 

National Healthcare Group, 2010/00675

 
Keywords: AIDS/HIV • imaging/image analysis: clinical • cytomegalovirus 
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