Purchase this article with an account.
Meira Neudorfer, Oriel Spierer, maya Ben-Amitai Hertman, Hadas Newman, Sarit Barak, Adiel Barak, Isca Asher-Landsberg; Optical Coherence Tomography in Preeclamptic Women. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2679.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Visual disturbances are possible among preeclamptic women including visual obscuration, photopsia, scotoma, visual loss and cortical blindness. There are sparse data on the prevalence of ocular involvement in preeclampsia especially among non symptomatic patients. The currently available information on the use of optical coherence tomography (OCT) in preeclampsia is based on case reports.The purpose of this study was to evaluate retinal and OCT findings in preeclamptic women.
The 27 preeclamptic women recruited for this study underwent ophthalmic and retinal OCT examinations. The size and location of ocular findings, involvement of the retinal layers and retinal nerve fiber layer (RNFL) thickness as determined by OCT were assessed. Data pertaining to preeclampsia were recorded and evaluated.
Four women (14.8%) had funduscopic findings related to preeclampsia: two had retinal hemorrhages and two had retinal edema. OCT revealed retinal pathology in 3 eyes (5.6%) of 2 patients (7.4%). There was a higher prevalence of ocular findings among women with severe preeclampsia accompanied by severe hypertension and/or neurological signs. OCT findings included: retinal edema, subretinal fluid, photoreceptors irregularities and lesions at the retinal pigment epithelium level (Elschnig spots). The choroid layer was normal. Peripapillary RNFL tended to be thicker in eyes with pathological findings on OCT.The figure below shows an OCT section through the fovea of a preeclamptic patient with ocular involvement. Subretinal fluid and RPE lesion (Elschnig spot) are noted.
The prevalence of ocular findings in both fundus and OCT examinations is relatively low in asymptomatic preeclamptic women. OCT was not more sensitive than funduscopy for detecting pathological ocular findings in preeclampsia, but it provided accurate definition and delineation of the findings. The fact that peripapillary RNFL tended to be thicker in eyes with pathological findings might be related to subclinical involvement of CNS. Given the unique ability of OCT to specifically define ocular findings in preeclampsia, we recommend that preeclamptic women diagnosed as having ocular involvement be evaluated and monitored by OCT.
This PDF is available to Subscribers Only