Purchase this article with an account.
Joseph B. Alsberge, Syed A. Hussnain, Joshua R. Ehrlich, Mitsugu Shimmyo, Nathan M. Radcliffe; The Association between Corneal Hysteresis and Various Intraocular Pressure Parameters. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2805.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
We sought to identify the intraocular pressure (IOP) parameter that best correlated with corneal hysteresis (CH) in a large database of patients with and without open-angle glaucoma (OAG).
In this retrospective study, we included patients with at least 10 office visits where Ocular Response Analyzer (ORA; Reichert Corp., Buffalo, NY) measurement was performed. Each ORA measurement was performed on a different day. Mean, peak, and standard deviation (SD) of Goldmann-correlated IOP were recorded, and Pearson correlation and linear regression were used to model the associations between IOP parameters and CH.
We included records from 957 normal and 291 treated OAG patients. The mean duration of follow-up for normal and OAG patients was 3.0 ± 1.4 and 4.4 ± 1.1 years and the mean number of ORA measurements was 17.9 ± 7.3 and 23.3 ± 10.1, respectively. In both normal and OAG patients, SD of IOP was the IOP parameter that correlated most strongly with both baseline (Normal: r=-0.28; OAG: r=-0.30) and most recent follow-up CH (Normal: r=-0.23; OAG: r=-0.36). Age (p<0.001), but not duration of follow-up (p≥0.23), was significantly associated with CH for normal and OAG patients. Multivariable analysis demonstrated a statistically significant inverse relationship between CH and SD of IOP after adjusting for age among both normal and OAG patients (p<0.001). The results were similar whether baseline or most recent follow-up CH was the independent variable and results were unchanged when censoring the first two office visits among OAG patients to account for initiation of IOP lowering therapy.
In both normal and OAG patients, SD of IOP was more strongly correlated with CH than mean and peak IOP, and a higher SD of IOP was associated with lower CH independent of age. Lower CH may be measured in patients with greater IOP fluctuation.
This PDF is available to Subscribers Only