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Cosima Hermann, Karin R. Pillunat, Olga Furashova, Eberhard Spoerl, Lutz E. Pillunat; Corneal Biomechanic Properties (CBP) and their correlation with IOP Fluctuation, Visual Field and Body Indices in glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2808.
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It has been shown that CBP might be correlated with glaucoma progression. In order to evaluate clinical features which might be correlated to CBP a prospective clinical trial was initiated.
146 eyes of 73 (mean age 63.2±11.4 years) glaucoma patients were included in a prospective, clinical trial. CBP were measured by means of the Ocular Response Analyzer (ORA, Reichert Inc.). Corneal Hysteresis (CH) was used as a measure of viscous properties of the cornea and the corneal resistance factor (CRF) was used as a measure of overall resistance of the cornea. Body Mass Index (BMI), height, weight, IOP, IOPcc (adjusted for corneal CH and CRF), IOP fluctuation and the visual field parameters PSD and MD were correlated with the results of ORA measurements. For statistical analysis a bivariate-correlation analysis was performed (P=0.05) for right eyes, left eyes and the whole sample.
Taking all measured eyes into account (146 eyes) CH was inversely, significantly correlated only with IOPcc (r = -0.49; P< 0.05). CRF was significantly correlated with IOP (r = 0.59), IOP fluctuation (r = 0.17), visual field progression (r =-0.19), MD (r = 0.29) and PSD (r = -0.31). CH and CRF showed no correlation with BMI, height and weight.
The Corneal Resistance Factor, which is a measure for overall corneal resistance and which might be also a measure for the biomechanical properties of the whole eye seems to be highly correlated with nearly all main parameters for glaucoma follow up. Therefore CRF seems to be of major importance in glaucoma diagnosis and future studies have to show, whether CRF measurements are of prognostic value.
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