March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
1060nm FD-OCT of Optic Nerve Head in Glaucoma Patients and Healthy Subjects
Author Affiliations & Notes
  • Barbara Kiss
    Ophthalmology,
    Medical Universtiy of Vienna, Vienna, Austria
  • Marieh Esmaeelpour
    Centre for Medical Physics and Biomedical Engineering,
    Medical Universtiy of Vienna, Vienna, Austria
  • Boris Povazay
    Centre for Medical Physics and Biomedical Engineering,
    Medical Universtiy of Vienna, Vienna, Austria
  • Martin F. Kraus
    Pattern Recognition Lab and School of Advanced Optical Technologies, University Erlangen Nuremberg, Erlangen, Germany
  • Stephan Holzer
    Ophthalmology,
    Medical Universtiy of Vienna, Vienna, Austria
  • Clemens Vass
    Ophthalmology,
    Medical Universtiy of Vienna, Vienna, Austria
  • Joachim Hornegger
    Pattern Recognition Lab and School of Advanced Optical Technologies, University Erlangen Nuremberg, Erlangen, Germany
  • Wolfgang Drexler
    Centre for Medical Physics and Biomedical Engineering,
    Medical Universtiy of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Ophthalmology,
    Medical Universtiy of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships  Barbara Kiss, None; Marieh Esmaeelpour, None; Boris Povazay, None; Martin F. Kraus, MIT (P); Stephan Holzer, None; Clemens Vass, None; Joachim Hornegger, MIT (P); Wolfgang Drexler, Carl Zeiss Meditec (C); Ursula Schmidt-Erfurth, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2818. doi:
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      Barbara Kiss, Marieh Esmaeelpour, Boris Povazay, Martin F. Kraus, Stephan Holzer, Clemens Vass, Joachim Hornegger, Wolfgang Drexler, Ursula Schmidt-Erfurth; 1060nm FD-OCT of Optic Nerve Head in Glaucoma Patients and Healthy Subjects. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2818.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To assess the morphologic properties of the human lamina cribrosa (LC) and surrounding structures of glaucoma patients and healthy subjects using three-dimensional high axial resolution (<8 µm) Frequency Domain - Optical Coherence Tomography (FD-OCT) at 1060 nm central wavelength.

Methods: : OCT scans were obtained in 30 eyes of glaucoma patients (21 eyes with typical glaucomatous field defects, 4 ocular hypertension, 4 suspects and 1 normal) and in healthy subjects using raster scanning of a 13x13° field at a resolution of 512x512 axial depth-scans. Imaging of the optic nerve, peripapillar and macular retina and choroid were performed. Perimetry 30-2 and 10-2 (HFA-II®,Zeiss), Scanning laser polarimetry (GDx®, Zeiss), retina tomography (HRT-II®, Heidelberg Engineering), axial eye length (IOL Master®, Zeiss), central corneal thickness, intraocular pressure and blood pressure were assessed, additionally.

Results: : Visual field mean deviations of the glaucomatous eyes were -7,24 ± 4,60 dB. The prelaminar and anterior laminar surface were identified in all eyes centrally. The hyperreflective LC was visualized with its pores left as vertical hyporeflective channels with characteristic deformations and depth-dependent changes in density and orientation.

Conclusions: : High definition and three-dimensional imaging at a wavelength of 1060nm enables visualization of the porous structure and thickness-evaluation of the lamina cribrosa in the glaucomatous and normal optic nerves.

Keywords: lamina cribrosa • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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