March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
The Diabetic Retinopathy Repair Project - Evaluation of choroidal morphology in diabetic retinopathy using optical coherence tomography
Author Affiliations & Notes
  • Pearse A. Keane
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Dawn A. Sim
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Simon Fung
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Javier Zarranz-Ventura
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Becky Smith
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Praveen J. Patel
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Marcus Fruttiger
    UCL Institute of Ophthalmology, London, United Kingdom
  • Catherine A. Egan
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Adnan Tufail
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Footnotes
    Commercial Relationships  Pearse A. Keane, None; Dawn A. Sim, None; Simon Fung, None; Javier Zarranz-Ventura, None; Becky Smith, None; Praveen J. Patel, Allergan (R), Novartis UK (R), Topcon UK (R); Marcus Fruttiger, None; Catherine A. Egan, None; Adnan Tufail, Allergan (C), GSK (C), Neuronsystems (C), Novartis (C), Thrombogenics (C)
  • Footnotes
    Support  National Institute of Health Research funding award to Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology as a Specialist Biomedical Research Centre for Ophthalmology
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2869. doi:
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      Pearse A. Keane, Dawn A. Sim, Simon Fung, Javier Zarranz-Ventura, Becky Smith, Praveen J. Patel, Marcus Fruttiger, Catherine A. Egan, Adnan Tufail; The Diabetic Retinopathy Repair Project - Evaluation of choroidal morphology in diabetic retinopathy using optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2869.

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Abstract

Purpose: : To assess choroidal thickness at the macula in subjects with diabetic retinopathy using enhanced depth imaging (EDI) optical coherence tomography (OCT).

Methods: : Data were retrospectively collected from 11 patients with diabetic retinopathy who underwent EDI-OCT scanning using a custom protocol (each image set consisted of 13 OCT B-scans obtained in a 20 x 15 degree horizontal raster pattern, and with each individual B-scan generated from 100 averaged scans). Raw OCT data were exported from the Spectralis instrument and imported into custom image analysis software. Choroidal thickness was then manually quantified with mean values obtained for each subfield of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid.

Results: : In a recent study, using a similar methodology but in a "normal" population, mean choroidal thickness in the macular region was found to be 287 µm. In the current study, average choroidal thickness in the macular region was found to be 200.73 ± 36.76 µm. In patients with diabetic retinopathy but no evidence of diabetic macular ischaemia, macular choroidal thickness was 220.13 ± 31.53 µm. However, in patients with diabetic macular ischaemia (n=6), macular choroidal thickness was 191.03 ± 39.37 µm.

Conclusions: : Evaluation of the choroid in patients with diabetic retinopathy may allow generation of clinically relevant morphologic parameters as well as providing new insights into mechanisms of visual loss in this disease.

Keywords: diabetic retinopathy • imaging/image analysis: clinical • choroid 
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