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Luiz H. Lima, Ketan Laud, Freund K. Bailey, Lawrence Yannuzzi,, Richard F. Spaide; Acquired Vitelliform Lesion Associated with Large Drusen. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2905.
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To describe the association of acquired vitelliform lesion (AVL) and large drusen in patients with non-neovascular age-related macular degeneration (AMD)
A retrospective review of clinical examination and multimodal imaging data of patients with AVL and large drusen seen over a 12-month period was performed. AVL was defined as subretinal accretion of yellowish material within the macular region. Large drusen was diagnosed by the presence of mounded deposits in the sub-retinal pigment epithelium (RPE) space between the RPE and the Bruch's membrane using multimodal imaging analysis (color photography, autofluorescence and spectral domain optical coherence tomography)
Thirteen eyes of 9 Caucasian patients with a mean age of 74 years were observed to have AVL associated with large drusen. The median visual acuity was 20/60. All AVL's were hyperautofluorescent and were located in the subretinal space between the RPE and the photoreceptor inner segment/outer segment junction. The AVL's in this series had similar color, autofluorescence, and optical coherence tomographic findings as the AVL`s seen in association with cuticular drusen and subretinal drusenoid deposits
AVLs, which have previously been related to cuticular drusen and subretinal drusenoid deposits, can occur in association with large drusen. Formation of drusen has been related to a complex interplay between RPE function, lipid transport, and inflammation. Abnormalities leading to drusen formation or processes that function in parallel to these may be causative in AVL formation
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