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Lauren E. Fereday, Lisa Pradillo, Neil F. Notaroberto, Michael K. Smolek; Do Blue-Blocking IOLs Affect Retinal Sensitivity?. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3069.
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To retrospectively compare retinal light sensitivity in patients who have received intraocular lenses (IOLs) that were either clear (CLR-IOL) or had a blue-blocking (BB-IOL) yellow tint. It has been shown elsewhere that a significant change in the macular pigment optical density (MPOD) occurs in patients with BB-IOLs. Photopic luminance contrast is also apparently affected by the tint. In addition, short-wavelength perimetry may be affected by yellow tint, but not standard perimetry. We believe microperimetry has not been previously used to compare CLR-IOL and BB-IOL patients both pre- and postoperatively, which is the objective of this study.
Patients gave informed consent for use of medical records for research. Inclusion criteria were IOL patients who had MAIA macular analyzer (Centervue, SpA; Padova, Italy) microperimetry performed both pre- and postoperatively. Study exclusion criteria included vision-related diseases other than cataract, or an incomplete MAIA examination. Preoperatively, 16 CLR-IOL and 95 BB-IOL examinations were used, and postoperatively, 10 CLR-IOL and 66 BB-IOL examinations were used. The MAIA default expert staircase method was applied and sensitivity was measured in decibels (dB) at 36 points in the macula. Central stimuli were measured, but analyzed separately.
Pre-and postoperative mean retinal sensitivity in the CLR-IOL and BB-IOL groups are shown in the Figure. A significant difference between the CLR-IOL and BB-IOL groups was found preoperatively (p <0.001); however, there was no significant (N.S.) difference between the groups post-operatively, with both groups having normal mean retinal sensitivity. Both groups showed significant improvement in mean retinal sensitivity between the pre- and postoperative periods due to cataract removal (p <0.001). Central stimuli data had similar significance.
Although the CLR-IOL and BB-IOL groups started at significantly different levels of mean retinal sensitivity due to varying cataract densities, the two groups were statistically identical and clinically normal in mean sensitivity after the procedure. This result confirms that there is no significant difference in the ability of postoperative CLR-IOL and BB-IOL patients to detect threshold white light stimuli.
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