March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Wide-field Spectral-domain Polarization-sensitive OCT (PS-OCT) For Imaging Of The Retinal Pigment Epithelium (RPE) In Age-related Macular Degeneration (AMD): From Bench To Bedside
Author Affiliations & Notes
  • Ursula Schmidt-Erfurth
    Department of Ophthalmology,
    Medical University of Vienna, Vienna, Austria
  • Matthias Bolz
    Department of Ophthalmology,
    Medical University of Vienna, Vienna, Austria
  • Stefan Zotter
    Center for Medical Physics and Biomedical Engineering,
    Medical University of Vienna, Vienna, Austria
  • Philipp K. Roberts
    Department of Ophthalmology,
    Medical University of Vienna, Vienna, Austria
  • Michael Pircher
    Center for Medical Physics and Biomedical Engineering,
    Medical University of Vienna, Vienna, Austria
  • Christopher Kiss
    Department of Ophthalmology,
    Medical University of Vienna, Vienna, Austria
  • Erich Goetzinger
    Center for Medical Physics and Biomedical Engineering,
    Medical University of Vienna, Vienna, Austria
  • Ramzi G. Sayegh
    Department of Ophthalmology,
    Medical University of Vienna, Vienna, Austria
  • Christoph K. Hitzenberger
    Center for Medical Physics and Biomedical Engineering,
    Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships  Ursula Schmidt-Erfurth, None; Matthias Bolz, None; Stefan Zotter, Canon (F); Philipp K. Roberts, Canon (F); Michael Pircher, Canon (F); Christopher Kiss, None; Erich Goetzinger, Canon (F); Ramzi G. Sayegh, None; Christoph K. Hitzenberger, Canon (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3081. doi:
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      Ursula Schmidt-Erfurth, Matthias Bolz, Stefan Zotter, Philipp K. Roberts, Michael Pircher, Christopher Kiss, Erich Goetzinger, Ramzi G. Sayegh, Christoph K. Hitzenberger; Wide-field Spectral-domain Polarization-sensitive OCT (PS-OCT) For Imaging Of The Retinal Pigment Epithelium (RPE) In Age-related Macular Degeneration (AMD): From Bench To Bedside. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3081.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To introduce a novel wide-field polarization sensitive (PS) OCT instrument for imaging retinal and RPE lesions in patients with dry and wet AMD in clinical practice.

 
Methods:
 

A new high-speed, wide-field, spectral-domain PS-OCT instrument was developed. The instrument operates at an A-scan rate of 70 kHz and supports scan angles of up to 40 x 40°. A new detection spectrometer design provides superior sensitivity roll-off of ~ 8 dB over 1.8 mm imaging depth, enabling improved visualization of lesions and structures with large depth extensions. Various scan patterns, ranging from 512 x 128 (1.1 sec) to 1024 x 250 (4.2 sec) are available. Reflectivity, retardation, optic axis orientation, and degree of polarization uniformity (DOPU) can be measured simultaneously. Additional software implemented comprised corneal birefringence compensation and RPE segmentation based on depolarization.

 
Results:
 

140 eyes of 105 patients with neovascular/atrophic AMD were measured with different scan patterns. Automated RPE segmentation based on DOPU values was applied. Several lesion types could be analyzed in a qualitative and quantitative way, and integrity/alteration of the RPE was evaluated based on its depolarizing properties: Different drusen types are identified, the size of geographic atrophies (GA) can be quantified. The level of RPE destruction in neovascular lesions is documented. The large scan angle allows to evaluate even large lesions. The technology is in development for wide-spread clinical use.

 
Conclusions:
 

The large field of view, high speed and superior signal quality of the novel PS-OCT technology will allow clinicians to identify lesion characteristics using automated qualitative and quantitative imaging.  

 
Keywords: age-related macular degeneration • imaging/image analysis: clinical • retinal pigment epithelium 
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