Purchase this article with an account.
Alex Fonollosa, Joseba Artaraz, Agustin Martinez-Berriotxoa, Marta Galdos, Sergio Pinar, Nerea Martinez-Alday; Chronopathology of Serpiginous Choroiditis lesions: an Autofluorescence and Spectral Domain-OCT study. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3205.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To describe the evolution of fundus autofluorescence (FAF) and Spectral domain-Optical Coherence Tomography (SD-OCT) alterations of Serpiginous Choroiditis (SC) lesions throughout time since acute stage until resolution of inflammation.
This is a retrospective case series. Serial FAF and SD-OCT images from 7 patients with SC performed since lesions presented active inflammation until they became inactive were reviewed.
Twenty two lesions of 7 patients were included. There were 5 woman and 2 men. Mean age was 59.6 years. Five cases were classified as classic SC , 1 case as Ampiginous choroiditis and 1 case as presumed tubercular serpiginouslike choroiditis. Mean follow-up was 14 months. The most complete sequence of changes in FAF from active inflammation of the lesion to absolute resolution of inflammatory activity were observed in 3 patients and consisted of: 1: Faint hypoautofluorescence surrounded by a thin halo of hyperautofluorescence . 2: hyperautofluorescence of the lesion with hypoautofluorescent spots surrounded by a thin hypoautofluorescent ring. 3: Progressive darkening of the lesion until complete hypoautofluorescence. In 4 of the patients FAF changes were only observed since hyperautofluorescence phase on. Funduscopy also showed a sequence of alterations since active stage until resolution. In symptomatic patients, funduscopy showed signs of inflammatory activity earlier than FAF. The most complete sequence of changes in SD-OCT from active inflammation of the lesion to absolute resolution of inflammatory activity were observed in 2 patients and consisted of: 1. Hyperreflective lesion in the external retina (which corresponded to the earliest inflammatory sign of activity in funduscopy). 2: Disruption of the third hyperreflective band and thickening of the retinal pigment epithelium (RPE) (which corresponded to hyperautofluorescence of the lesion with hypoautofluorescent spots surrounded by a thin hypoautofluorescent ring). 3: Disruption of third hyperreflective band and of the RPE (which corresponded to hypoautofluorescence of the lesion).
Evolutive morphological changes of lesions of SC since acute stage until chronic stage can be observed with both FAF and SD-OCT imaging. These diagnostic techniques may help to assess properly the inflammatory activity of the disease and hence determine the level of immunosuppression needed in every case.
This PDF is available to Subscribers Only