March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Relationship Between Ocular Manifestations And Cardiac Lesion In Sarcoidosis
Author Affiliations & Notes
  • Akihiko Umazume
    Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan
  • Takeshi Kezuka
    Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan
  • Yoko Okunuki
    Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan
  • Yoshihiko Usui
    Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan
  • Masayo Ooshita
    Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan
  • Hiroshi Goto
    Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan
  • Footnotes
    Commercial Relationships  Akihiko Umazume, None; Takeshi Kezuka, None; Yoko Okunuki, None; Yoshihiko Usui, None; Masayo Ooshita, None; Hiroshi Goto, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3216. doi:
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      Akihiko Umazume, Takeshi Kezuka, Yoko Okunuki, Yoshihiko Usui, Masayo Ooshita, Hiroshi Goto; Relationship Between Ocular Manifestations And Cardiac Lesion In Sarcoidosis. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3216.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Sarcoidosis is a multisystemic granulomatous disease of unknown etiology. The major organs involved in sarcoidosis are the lungs, skin, lymph nodes, heart and eyes. Especially, cardiac sarcoidosis is known to be a risk factor of sudden death. In this study, we aimed to investigate the potential relation between ocular sarcoidosis and cardiac lesions.

Methods: : We reviewed the clinical records of 102 consecutive patients who were diagnosed with ocular sarcoidosis based on the new diagnostic criteria in Japan. We examined gender, age, disease duration, tuberculin skin reaction, cardiac sarcoidosis, and various intraocular lesions including atrophic multiple chorioretinal peripheral lesions (AMCPL). Complication of C-sarcoidosis was laid down a definition of progress to put in a pacemaker.

Results: : Six patients (6%; 1 male and 5 females, mean age 63.8±3.43) had concurrent cardiac sarcoidosis, five of whom had complete atrioventricular block and one had ventricular septum hypomotility. In addition, all six patients had negative tuberculin reaction. Twenty-seven of 102 patients (26%) were found to have AMCPL as ocular findings of sarcoidosis. AMCPL were observed in 5 of 6 patients (83%) with cardiac sarcoidosis. The presence of AMPCL correlated significantly with concurrent cardiac sarcoidosis (p<0.05). All other intraocular findings were not related to cardiac sarcoidosis.

Conclusions: : The presence of atrophic multiple chorioretinal peripheral lesions correlates positively with cardiac sarcoidosis, suggesting a need for systemic work-up in patients manifesting these ocular sarcoidosis lesions.

Keywords: autoimmune disease • clinical (human) or epidemiologic studies: outcomes/complications • retinitis 
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