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Claudia H. Metz, Norbert Bornfeld, Friedrich Otterbach, Mete Goek; Malignant Uvea Melanoma and Suspected Vitreous Seeding. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3387.
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We analyzed 12 cases of suspected vitreous seeding and compared clinical and histopathological findings.
In a non-randomized, retrospective, interventional, non-comparative case series patients (vitrectomy performed between 2000 and 2011) suspected to have vitreous seeding of malignant melanoma of the uvea after local brachytherapy or without prior treatment were reviewed.
In 12 cases due to clinical suspected vitreous tumor disease a pars plana vitrectomy was performed. Nine patients have been treated by local plaque brachytherapy prior vitreous biopsy, while one patient has received proton beam irradiation and two patients have not been treated prior vitrectomy. Histopathological findings revealed melanophages in seven subjects without proof of vital tumor cells, in three cases vital tumor cells were found in the vitreous body and in two cases melanophages and vital tumor cells were detected.
In case of suspected vitreous seeding prior or after treatment of malignant uvea melanoma it is essential to take a vitreous biopsy to detect potential tumor disease, so that - if present - vital tumor manifestation can be successfully treated.
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