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Fouad E. Sayyad, Carol L. Karp, Leejee H. Suh, Sonia H. Yoo, Patrick Oellers, Andre C. Romano, Sander R. Dubovy, Richard K. Lee; Anterior Segment OCT (RTVue) for Diagnostic Imaging of Ocular Surface Pathology. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3623.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the use of enhanced RTVue OCT imaging for the diagnostic imaging of ocular surface lesions.
High resolution images were scanned of various ocular surface lesions using the RTVue OCT. The RTVue line scan setting was configured to image up to 100 frames to generate an averaged B-scan image. This technique resulted in reduced speckle noise and enhanced image contrast for improved visualization of the ocular surface and anterior segment tissues. Thirty ocular surface lesions were imaged: 10 ocular surface neoplasia, 6 pigmented conjuctival lesions, 1 lymphoma, 2 anterior corneal dystrophies, 4 pterygia, 4 pingueculae, and 3 corneal epithelial ingrowths. These scans were then correlated to clinical photographs and histopatholology.
The OCT images provided high correlation with the clinical images and histopathology. When the clinical diagnosis was in doubt, the RTVue OCT images provided imaging details, which assisted in the management of these lesions. The RTVue was especially helpful in distinguishing ocular surface squamous neoplasia from benign surface lesions by showing a thickened epithelium and an abrupt transition from normal to abnormal epithelium in the neoplastic versus benign cases.
The correlation between RTVue anterior segment OCT imaging with clinical findings and histopathology was significant, and an important aid in the management of ocular surface lesions. OCT can be used as an adjunctive noninvasive technique to diagnose surface lesions.
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