March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Novel Ultrananocrystaline Diamond (UNCDTM) Clogless Coated Grids for Eye Aqueous Humor Drain for Glaucoma Treatment
Author Affiliations & Notes
  • Pablo Gurman
    Materials Science Division, Argonne National Laboratory, Argonne, Illinois
  • Orlando Auciello
    Materials Science Division, Argonne National Laboratory, Argonne, Illinois
  • Mario J. Saravia
    Retina, Hospital Universitario Austral, Tigre, Argentina
  • Alejandro Berra
    Pathology, University of Buenos Aires, Buenos Aires, Argentina
  • Footnotes
    Commercial Relationships  Pablo Gurman, patent disclosure (P); Orlando Auciello, patent disclosure (P); Mario J. Saravia, patent disclosure (P); Alejandro Berra, patent disclosure (P)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3737. doi:
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    • Get Citation

      Pablo Gurman, Orlando Auciello, Mario J. Saravia, Alejandro Berra; Novel Ultrananocrystaline Diamond (UNCDTM) Clogless Coated Grids for Eye Aqueous Humor Drain for Glaucoma Treatment. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3737.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

Develop an UNCD-coated membrane as a bioinert/biocompatible efficient (no fouling) aqueous humor drain device for treatment of glaucoma.

 
Methods:
 

The device includes a metallic multi-hole circular grid, for efficient eye drainage. The grid is coated with an encapsulating bioinert/biocompatible UNCD film, grown by microwave plasma or hot filament chemical vapor deposition (grain size 5 nm). The biocompatibility of the UNCD-coated grid was tested via implantation of UNCD-coated (Fig. 1a) and uncoated (Fig. 1b) toxic copper grids in the sclera of several NZ rabbit eyes. Cu was used as one of the grid materials to demonstrate the strong bioinertness/biocompatibility of the UNCD film.

 
Results:
 

The UNCD coating eliminates adhesion of proteins and cells due to its surface hidrofobicity, and protects the eye against toxicity of the metallic grid. Images and histology of uncoated implants showed signs of inflammation, vascularization and fibrosis at days 1, 2, and 14 (two of them were extruded), while coated implants showed neither signs of inflammation, or fibrosis or vascularization.Fig. 1. Pictures of implanted UNCD-coated Cu grid (a) (no rejection) and uncoated (b) (eye rejection).Implantations of 8 UNCD-coated grids (Ti, W) in 8 rabbit eyes showed similar results as those shown in Fig. 1.

 
Conclusions:
 

This work demonstrated a new integrated UNCD-coated grid for efficient eye aqueous humor drainage for treatment of glaucoma.  

 

 
Keywords: intraocular pressure • trabecular meshwork • outflow: trabecular meshwork 
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