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Pablo Gurman, Orlando Auciello, Mario J. Saravia, Alejandro Berra; Novel Ultrananocrystaline Diamond (UNCDTM) Clogless Coated Grids for Eye Aqueous Humor Drain for Glaucoma Treatment. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3737.
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© ARVO (1962-2015); The Authors (2016-present)
Develop an UNCD-coated membrane as a bioinert/biocompatible efficient (no fouling) aqueous humor drain device for treatment of glaucoma.
The device includes a metallic multi-hole circular grid, for efficient eye drainage. The grid is coated with an encapsulating bioinert/biocompatible UNCD film, grown by microwave plasma or hot filament chemical vapor deposition (grain size 5 nm). The biocompatibility of the UNCD-coated grid was tested via implantation of UNCD-coated (Fig. 1a) and uncoated (Fig. 1b) toxic copper grids in the sclera of several NZ rabbit eyes. Cu was used as one of the grid materials to demonstrate the strong bioinertness/biocompatibility of the UNCD film.
The UNCD coating eliminates adhesion of proteins and cells due to its surface hidrofobicity, and protects the eye against toxicity of the metallic grid. Images and histology of uncoated implants showed signs of inflammation, vascularization and fibrosis at days 1, 2, and 14 (two of them were extruded), while coated implants showed neither signs of inflammation, or fibrosis or vascularization.Fig. 1. Pictures of implanted UNCD-coated Cu grid (a) (no rejection) and uncoated (b) (eye rejection).Implantations of 8 UNCD-coated grids (Ti, W) in 8 rabbit eyes showed similar results as those shown in Fig. 1.
This work demonstrated a new integrated UNCD-coated grid for efficient eye aqueous humor drainage for treatment of glaucoma.
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