March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Physical Activity associated with Age-Related Macular Degeneration: The Tromsø Eye Study
Author Affiliations & Notes
  • Maja G. Erke
    Ophthalmology, University Hospital of North Norway, Tromsø, Norway
    Institute of Community Medicine, University of Tromsø, Tromsø, Norway
  • Geir Bertelsen
    Institute of Community Medicine, University of Tromsø, Tromsø, Norway
  • Anne K. Sjølie
    Ophthalmology, Odense University Hospital, Odense, Denmark
  • Tunde Peto
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, London, United Kingdom
    UCL Institute of Ophthalmology, London, United Kingdom
  • Haakon Lindekleiv
    Institute of Community Medicine, University of Tromsø, Tromsø, Norway
  • Inger Njølstad
    Institute of Community Medicine, University of Tromsø, Tromsø, Norway
  • Footnotes
    Commercial Relationships  Maja G. Erke, None; Geir Bertelsen, None; Anne K. Sjølie, None; Tunde Peto, None; Haakon Lindekleiv, None; Inger Njølstad, None
  • Footnotes
    Support  The Northern Norway Regional Health Authority grant SFP897-09
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3819. doi:
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      Maja G. Erke, Geir Bertelsen, Anne K. Sjølie, Tunde Peto, Haakon Lindekleiv, Inger Njølstad; Physical Activity associated with Age-Related Macular Degeneration: The Tromsø Eye Study. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3819.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To examine the association between age-related macular degeneration (AMD) and physical activity.

Methods: : Data from the population-based, cross-sectional Tromsø Eye Study conducted in 2007-8 in the municipality of Tromsø, Norway were analyzed. Digital color fundus photographs from 2631 Caucasians aged 65 to 87 years (mean 72.3 years, standard deviation ±5.3) were graded for AMD using the International classification. Risk factor exposure was collected from questionnaires and physical examination. Average physical activity past year was assessed by 4 questions regarding type of activity, frequency, duration and at which level exercise was typically performed. Active lifestyle was defined as exercising ≥2 times a week. Logistic regression calculated adjusted odds ratios (OR) with 95% confidence intervals (CI) for late AMD. Analyses were stratified by sex.

Results: : A significant negative association was found between late AMD and active lifestyle in women (OR 0.35, 95% CI 0.16-0.75), adjusted for age, compared to women never exercising. No association was found for men (OR 2.0, 95% CI 0.47-8.7). Further analysis controlling for age, smoking and visual impairment (Snellen ≤0.32) achieved OR 0.40, 95% CI 0.16-0.99, for women and OR 2.3, 95% CI 0.45-11.6, for men. No associations were observed between late AMD and the other variables of physical activity.

Conclusions: : Exercising ≥2 times a week was associated with lower prevalence of late AMD in women in multivariable analysis adjusted for age, smoking and visual impairment, but not in men.

Keywords: age-related macular degeneration • clinical (human) or epidemiologic studies: risk factor assessment 
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