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Maja G. Erke, Geir Bertelsen, Anne K. Sjølie, Tunde Peto, Haakon Lindekleiv, Inger Njølstad; Physical Activity associated with Age-Related Macular Degeneration: The Tromsø Eye Study. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3819.
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To examine the association between age-related macular degeneration (AMD) and physical activity.
Data from the population-based, cross-sectional Tromsø Eye Study conducted in 2007-8 in the municipality of Tromsø, Norway were analyzed. Digital color fundus photographs from 2631 Caucasians aged 65 to 87 years (mean 72.3 years, standard deviation ±5.3) were graded for AMD using the International classification. Risk factor exposure was collected from questionnaires and physical examination. Average physical activity past year was assessed by 4 questions regarding type of activity, frequency, duration and at which level exercise was typically performed. Active lifestyle was defined as exercising ≥2 times a week. Logistic regression calculated adjusted odds ratios (OR) with 95% confidence intervals (CI) for late AMD. Analyses were stratified by sex.
A significant negative association was found between late AMD and active lifestyle in women (OR 0.35, 95% CI 0.16-0.75), adjusted for age, compared to women never exercising. No association was found for men (OR 2.0, 95% CI 0.47-8.7). Further analysis controlling for age, smoking and visual impairment (Snellen ≤0.32) achieved OR 0.40, 95% CI 0.16-0.99, for women and OR 2.3, 95% CI 0.45-11.6, for men. No associations were observed between late AMD and the other variables of physical activity.
Exercising ≥2 times a week was associated with lower prevalence of late AMD in women in multivariable analysis adjusted for age, smoking and visual impairment, but not in men.
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