March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Hypodense Regions ("Holes") Are Seen in the Retinal Nerve Fiber Layer of the Frequency-Domain OCT Scans of Eyes with Glaucoma, but not Eyes with MS or ION
Author Affiliations & Notes
  • Daiyan Xin
    Psychology, Einhorn Clinical Research Center,
    Columbia University, New York, New York
  • Danilo B. Fernandes
    Psychology, Einhorn Clinical Research Center,
    Columbia University, New York, New York
  • Matthew Nguyen
    Psychology, Einhorn Clinical Research Center,
    Columbia University, New York, New York
  • Christine L. Talamini
    Psychology, Einhorn Clinical Research Center,
    Columbia University, New York, New York
  • Gustavo V. De Moraes
    Psychology, Einhorn Clinical Research Center,
    New York Eye & Ear Infirmary, NYU School of Medicine, New York, New York
  • Jeffrey G. Odel
    Ophthalmology, Ophthalmology,
    Columbia University, New York, New York
  • Jeffrey M. Liebmann
    Ophthalmology, Ophthalmology,
    New York Eye & Ear Infirmary, NYU School of Medicine, New York, New York
  • Robert Ritch
    Ophthalmology, New York Eye & Ear Infirmary, New York Medical College, New York/Valhalla, New York
  • Donald C. Hood
    Psychology and Ophthalmology,
    Columbia University, New York, New York
  • Footnotes
    Commercial Relationships  Daiyan Xin, None; Danilo B. Fernandes, None; Matthew Nguyen, None; Christine L. Talamini, None; Gustavo V. De Moraes, None; Jeffrey G. Odel, None; Jeffrey M. Liebmann, Topcon Corporation (F); Robert Ritch, None; Donald C. Hood, Topcon Corporation (F)
  • Footnotes
    Support  NIH grant EY02115
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 3914. doi:
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      Daiyan Xin, Danilo B. Fernandes, Matthew Nguyen, Christine L. Talamini, Gustavo V. De Moraes, Jeffrey G. Odel, Jeffrey M. Liebmann, Robert Ritch, Donald C. Hood; Hypodense Regions ("Holes") Are Seen in the Retinal Nerve Fiber Layer of the Frequency-Domain OCT Scans of Eyes with Glaucoma, but not Eyes with MS or ION. Invest. Ophthalmol. Vis. Sci. 2012;53(14):3914.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To see if eyes with ischemic optic neuropathy (ION) or optic neuritis/multiple sclerosis (ON/MS) exhibit hypodense regions ("holes") in the retinal nerve fiber layer (RNFL) of frequency-domain optic coherence tomography (fdOCT) scans, as previously reported for glaucoma patients (GL) and glaucoma suspects (GLS).[1]

Methods: : Peripapillary circle (1.7 mm radius) and 3D optic disc fdOCT scans (Topcon 3D OCT 2000) were obtained on 63 eyes of 34 patients (39.6 ± 12.8 yrs) with ON/MS; 25 eyes of 15 patients (58.4 ± 10.5 yrs) with ION; 119 eyes of 63 patients (56.8 ± 14.5 yrs) with glaucomatous optic neuropathy (GON) and visual field mean deviations better than -6 dB. Patients were excluded if they did not have good quality scans and reliable 24-2 visual fields (Zeiss Meditec). Holes in the RNFL on circle scans were identified independently by 2 observers. The presence of holes also was verified on successive slices of 3D disc scans.

Results: : A total of 60 holes were found in 16 of the eyes of the GL/GLS patients, with 12 eyes showing more than one location with a hole. Conversely, none of the 25 ION eyes and only one eye with ON/MS had a hole. That is, one or more holes were found in 13.4% of the GL/GLS eyes, 0% of the ION eyes, and 1.6% of the ON/MS eyes. Severity of visual field loss as measured by mean deviations (MD) or thinning of the RNFL did not explain the differences among the groups.

Conclusions: : As previously reported for a different group of GL/GLS patients, holes are seen in the RNFL of patients with GON, even in eyes of glaucoma suspects with normal visual fields.[1] These holes, which are likely due to a local loss of retinal nerve fibers, are not seen in healthy controls [1] and seldom seen in patients with damage to the optic nerve secondary to ION or ON/MS.1. Xin et al, IOVS, 2011, 9, 7180.

Keywords: neuro-ophthalmology: optic nerve • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical 
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