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Alain Saad, Damien Gatinel; Wavefront profile of Ectasia Susceptible Corneas. Invest. Ophthalmol. Vis. Sci. 2012;53(14):4030.
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To investigate the application of anterior corneal and ocular aberrations in detecting mildly ectatic corneas.
We retrospectively reviewed the data of 220 eyes separated into 3 groups by the Nidek Corneal Navigator System automated corneal classification software: normal (N) (n=123), Forme Fruste Keratoconus (N Topography with contralateral KC) (FFKC) (n=34) and KC (n=63). Anterior corneal and ocular aberrations were obtained with the OPD Scan and compared using a Kruskall Wallis test. Evaluation of these data to discriminate between the three groups was assessed using a Receiver-Operating Characteristic (ROC) curve analysis.
Corneal and Ocular tilt, vertical coma and trefoil were significantly different in the FFKC as compared to the N group however their clinical relevance was small. The association of individual Zernike coefficients in a discriminant function differentiates between FFKC and normal corneas with a sensitivity of 91% and a specificity of 94%. The discriminant functions between the FFKC and the N group and between the KC and the N group reached an Area under the ROC curve of 0.98 and 0.96 respectively.
Indices generated from corneal and ocular wavefront can identify very mild forms of ectasia that may be undetected by a Placido-based neural network programs.
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