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Dae Hyun Kim, Mu O Jung, Gwang Ju Choi; Concentration Of Pigment Epithelium Derived Factor In The Vitreous And Serum Of Retinal Detachment. Invest. Ophthalmol. Vis. Sci. 2012;53(14):4617.
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To determine the vitreous and serum levels of pigment epithelium derived factor(PEDF) in rhegmatogenous retinal detachment (RRD) patients and to find out the relationship between PEDF level and the characteristic of the retinal detachment (duration of the disease and number of involved quadrants).
Vitreous samples were collected from 25 eyes of 25 patients with RRD undergoing vitrectomy for retinal reattachment and eighteen serum samples were also collected from the patients. The concentration of PEDF was determined by enzyme-linked immunosorbent assay (ELISA).
The mean concentration of PEDF was 3.62 ± 1.68 μg/ml(mean ± standard deviation) in 25 vitreous samples collected from the patients with RRD. It was higher than the mean concentration of 2.07± 1.29 μg/ml in 18 vitreous samples from the control group (p > 0.05). The mean concentration of PEDF was 2.26 ± 0.92 μg/ml in 18 samples of the serum collected from the patients with RRD. It was lower than the PEDF concentration of 3.04 ± 0.71 μg/ml in 18 samples of the serum collected from the control (group) (p< 0.05). The mean vitreous PEDF level ( 3.36 ± 1.68μg/ml) was significantly higher than the serum level( 2.26 ± 0.92μg/ml) in the same 18 RRD patients. The duration of RRD was significantly correlated with the concentration of PEDF in vitreous humor (r=0.836, p<0.05). There was no significant correlation between the concentration of PEDF in vitreous humor and number of involved quadrants(r=0.288, p>0.05).
The vitreous level of PEDF in RRD patients were significantly higher than the control group. In contrast to vitreous PEDF, serum level of PEDF in RRD was significantly lower than the control group. As the duration of RRD was longer, the vitreous level of PEDF was higher.
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