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Rene Hoehn, Christina Butsch, Isabella Zwiener, Stefan Blankenberg, Norbert Pfeiffer, Alireza Mirshahi; Optic Disc Drusen: Prevalence, ocular and systemic associations in the Gutenberg Health Study. Invest. Ophthalmol. Vis. Sci. 2012;53(14):4885. doi: https://doi.org/.
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To determine the prevalence and ocular and systemic associations of optical visible optic disc drusen (ODD) in a large Caucasian cohort.
The Gutenberg Health Study (GHS) is a population-based, prospective, observational cohort study in the Rhine-Main Region in midwestern Germany with a total of about 15000 participants and follow-up after five years. The study sample is recruited from subjects aged between 35 and 74 years at the time of the exam. Participants undergo a standardized protocol with a comprehensive questionnaire, an ophthalmic examination including slitlamp biomicroscopy, non-contact tonometry, fundus photography, central corneal thickness measurement and visual field testing. Furthermore, a complete general examination focused on cardiovascular parameters, psychosomatic evaluations and laboratory tests including genetic analysis are performed. The first 5000 participants, which are stratified by gender, residence (urban and rural) and decade of age, were included into analysis and fundus photographs of 4594 right eyes and 4510 left eyes were eligible for evaluation. Optic disc photographs (30° non-stereoscopic) were reviewed to assess prevalence of optical visible ODD. Association analyses with ocular and cardiovascular parameters were performed.
Prevalence of ODD was 0.5% (n = 47). There was no statistically significant difference between left and right eyes. No gender preference was observed. A negative spherical equivalent (OR 0.88, p = 0.006 in right eyes and OR 0.90, p = 0.029 in left eyes) were associated with a lower risk of ODD. ODD were detected more often with higher IOP (OR 1.19, p < 0.001 in right eyes and OR 1.25, p < 0.001 in left eyes) and with visual field defects (OR 2.34, p = 0.080 in right eyes and OR 3.13, p = 0.0046 in left eyes). No associations were found for cardiovascular risk factors, such as blood pressure, diabetes, smoking or body mass index.
This is the first population-based study providing data on the prevalence of optic disc drusen in Caucasians. The prevalence was twofold higher than in Asian populations. Furthermore, we revealed that higher IOP and visual field defects are associated with the occurrence of ODD. Myopic individuals are less affected of ODD.
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