March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Comparison of 24-hour efficacy with Tafluprost compared with Latanoprost in patients with Primary Open-Angle glaucoma or Ocular Hypertension
Author Affiliations & Notes
  • Anastasios-Georgios P. Konstas
    1st University Dept of Ophthalmology, AHEPA University Hospital, Thessaloniki, Greece
  • Luciano Quaranta
    Ophthalmology, University of Brescia, Brescia, Italy
  • Theodoros Giannopoulos
    1st University Dept of Ophthalmology, AHEPA University Hospital, Thessaloniki, Greece
  • Ivano Riva
    Ophthalmology, University of Brescia, Brescia, Italy
  • Andreas Katsanos
    Ophthalmology, University of Ioannina, Ioannina, Greece
  • Irini C. Voudouragkaki
    1st University Dept of Ophthalmology, AHEPA University Hospital, Thessaloniki, Greece
  • Eleni Paschalinou
    1st University Dept of Ophthalmology, AHEPA University Hospital, Thessaloniki, Greece
  • Irene Floriani
    Mario Negri Institute, Milan, Italy
  • Anna-Bettina Haidich
    Dept of Hygiene, Aristotle University, Thessaloniki, Greece
  • Footnotes
    Commercial Relationships  Anastasios-Georgios P. Konstas, Alcon, Allergan, MSD (C), Alcon, Allergan, MSD, Pfizer (R); Luciano Quaranta, Alcon, Allergan, MSD, Thea Farmila, Bauch & Lomb (R); Theodoros Giannopoulos, None; Ivano Riva, Allergan, MSD (R); Andreas Katsanos, Alcon, Allergan (R); Irini C. Voudouragkaki, None; Eleni Paschalinou, None; Irene Floriani, None; Anna-Bettina Haidich, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 5104. doi:
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      Anastasios-Georgios P. Konstas, Luciano Quaranta, Theodoros Giannopoulos, Ivano Riva, Andreas Katsanos, Irini C. Voudouragkaki, Eleni Paschalinou, Irene Floriani, Anna-Bettina Haidich; Comparison of 24-hour efficacy with Tafluprost compared with Latanoprost in patients with Primary Open-Angle glaucoma or Ocular Hypertension. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5104.

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Abstract

Purpose: : To compare the 24-hour intraocular pressure (IOP) control obtained with preservative-free tafluprost to preservative-containing latanoprost when both are administered as first choice therapy in patients with primary open-angle glaucoma (POAG), or ocular hypertension (OHT).

Methods: : Prospective, observer-masked, crossover comparison. The study included consecutive, newly-diagnosed patients with POAG, or OHT and baseline IOP between 24-33 mm Hg. All patients underwent a baseline untreated 24-hour IOP curve measured in habitual positions, with Goldmann sitting tonometry at 10:00, 14:00, 18:00, 22:00 and Perkins supine tonometry at 02:00 and 06:00. They were then randomized to either latanoprost, or tafluprost administered in the evening for 3 months and then switched to the opposite therapy for another 3 months. At the end of each treatment period patients underwent a 24-hour IOP evaluation.

Results: : Thirty-eight patients with POAG or OHT completed the study. The mean untreated 24-hour IOP (24.9 mm Hg) was significantly reduced with both prostaglandin analogues (P<0.001). When the two drugs were compared directly, tafluprost demonstrated similar mean 24-hour efficacy compared with latanoprost (17.8 vs 17.7 mm Hg, P=0.417). A small, non-significant efficacy superiority of latanoprost during the period between 10:00-18:00 (0.4-0.5 mm Hg) reversed during the period between 22:00-06:00 (-0.2-0.4 mm Hg). Latanoprost provided significantly better 24-hour trough IOP (15.9 vs 16.3 mm Hg, P=0.041), whereas tafluprost provided significantly lower 24-hour IOP fluctuation (3.21 vs 3.84 mm Hg, P=0.008). No significant difference existed between the two prostaglandins for any adverse event.

Conclusions: : In this crossover study, preservative-free tafluprost employed as first choice therapy achieved statistically similar 24-hour IOP reduction when compared to latanoprost. The mean 24-hour difference between the two prostaglandins was 0.1 mm Hg. The current study highlights the importance of complete assessment of efficacy over 24 hours.

Clinical Trial: : http://www.clinicaltrials.gov NCT01162603

Keywords: intraocular pressure • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • circadian rhythms 
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