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Takanori Kameda, Masako Kuroda, Hiroshi Kojima, Yasuhiko Hirami, Fumitaka Hirose, Noriko Miyamoto, Michiko Mandai, Yasuo Kurimoto; Occurrence of Myopic Choroidal Neovascularization and Relative Extent of Ocular Elongation to Width. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5185.
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© ARVO (1962-2015); The Authors (2016-present)
In high myopic eyes, damage to the Bruch’s membrane due to mechanical axial elongation is considered one of the major causes of the development of myopic choroidal neovascularization (mCNV). The purpose of the study was to analyze whether not only the measured axial elongation but the relative extent of elongation (ocular length/width) in high myopic eyes could contribute to the occurrence of mCNV.
We investigated 116 high myopic eyes of 62 patients (male 29, female 33) from Kobe City Medical Center General Hospital (mean age 63.3 ± 14.0 years old). Swept-source optical coherence tomography (SSOCT, CASIA®, TOMEY) was used to measure anterior chamber width (ACW), which was measured as a length between the nasal and temporal scleral spurs in an obtained SSOCT horizontal line. Relative ratio of ACW and axial length (ACW/AL ratio) was defined as ocular elongation index.
The mean AL and ACW were 27.89 ± 1.76 mm and 11.85 ± 0.49 mm, respectively. Twenty-two eyes of 21 patients had mCNV. There were significant negative correlations between age and ACW, and between age and ACW/AL ratio (p < 0.05). The mCNV was present more frequently in female patients (p < 0.05). Although there was no significant difference in axial length between both sexes, female patients had significantly smaller ACW (11.67 ± 0.06 mm vs 12.04 ± 0.06 mm, p < 0.05) and ACW/AL ratio (0.419 ± 0.004 vs 0.433 ± 0.004, p < 0.05). ACW/AL was significantly smaller in eyes with mCNV (0.413 ± 0.006 vs 0.429 ± 0.003, p < 0.05).
ACW/AL ratio was considered a useful index to express relative ocular elongation. The mCNV may occur more frequently in relatively elongated eyes.
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