March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Detection Of Sub-threshold Laser Irradiation Spots With Various Fundus Imaging Methods And Its Correlation With Irradiation Energy And Optoacoustic Values In Selective Retina Therapy
Author Affiliations & Notes
  • Kumiko Yoshimoto
    Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, Osaka-shi, Japan
  • Manabu Yamamoto
    Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, Osaka-shi, Japan
  • Takeya Kohno
    Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, Osaka-shi, Japan
  • Tasuku Yoneda
    Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, Osaka-shi, Japan
  • Yusaku Yoshida
    Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, Osaka-shi, Japan
  • Andreas Fritz
    Institute of Biomedical Optics, University of Luebeck, Luebeck, Germany
  • Dirk Theisen-kunde
    Institute of Biomedical Optics, University of Luebeck, Luebeck, Germany
  • Yoko Miura
    Institute of Biomedical Optics, University of Luebeck, Luebeck, Germany
    Institute of Biomedical Optics, University of Luebeck, Luebeck, Germany
  • Ralf Brinkmann
    Institute of Biomedical Optics, University of Luebeck, Luebeck, Germany
  • Kunihiko Shiraki
    Ophthalmology and Visual Sciences, Osaka City University Graduate School of Medicine, Osaka-shi, Japan
  • Footnotes
    Commercial Relationships  Kumiko Yoshimoto, None; Manabu Yamamoto, None; Takeya Kohno, None; Tasuku Yoneda, None; Yusaku Yoshida, None; Andreas Fritz, None; Dirk Theisen-kunde, None; Yoko Miura, None; Ralf Brinkmann, None; Kunihiko Shiraki, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 5198. doi:
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      Kumiko Yoshimoto, Manabu Yamamoto, Takeya Kohno, Tasuku Yoneda, Yusaku Yoshida, Andreas Fritz, Dirk Theisen-kunde, Yoko Miura, Ralf Brinkmann, Kunihiko Shiraki; Detection Of Sub-threshold Laser Irradiation Spots With Various Fundus Imaging Methods And Its Correlation With Irradiation Energy And Optoacoustic Values In Selective Retina Therapy. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5198.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate frequencies of detecting sub-threshold laser irradiation spots of selective retina therapy (SRT) with different fundus imaging methods and to examine the usefulness of optoacoustic value (OA) that was developed as an indicator of RPE cell destruction through optoacoustic signals from bubble formation inside the RPE cells.

Methods: : After applying laser irradiation in 9 eyes of 9 CSCR patients with SRT laser (frequency-doubled, pulse-stretched Nd:YLF laser; 527 nm, 1.7 µs pulse duration, 100-Hz repetition rate), fluorescein and indocyanine green angiography (FA, IA) and fundus autofluorescence (FAF) pictures were taken. The OA values were obtained during irradiation. A fundus camera (FC) and a confocal scanning laser ophthalmoscopy (cSLO) were used for FA, IA and FAF. Additionally, two different excitation filters (520 and 580 nm) were used for FAF with a FC. Frequency of detecting laser irradiation spots was examined regarding each fundus imaging method. The correlation between irradiation energy and OA values and another between the fundus appearance of irradiation spots and its irradiation energy or OA values were analyzed.

Results: : The frequencies of spot detection with FC-FA, cSLO-FA, FC-IA, cSLO-IA, FC520-FAF, FC580-FAF and cSLO-FAF were 93%, 95%, 92%, 97%, 81%, 94% and 32%, respectively. The OA values were closely correlated with the irradiated laser energy (R=0.87, p<0.001). Test spot appearances in FA, IA and FA-FAF were highly correlated with both irradiation energy and OA value.

Conclusions: : A cSLO-IA showed the highest frequency of detecting SRT irradiation spots. Moreover, the OA value was considered appropriate to determine treatment energy strength.

Clinical Trial: : http://www.umin.ac.jp, UMIN000005396

Keywords: macula/fovea • laser • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials 
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