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Linda Y. Huang, Jing Jing Feng, Marcelino Potian, Anuradha Patel, Catherine Schoenberg, Xiuru Sun, Dennis Grech, Neelakshi Bhagat; Comparison of Dexmedetomidine Sedation vs. Propofol in Vitreoretinal Surgery Under Local Block. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5382.
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To compare the efficacy of dexmedetomidine (dex) vs. propofol (prop) in vitreoretinal surgery under local block.
An IRB approved double-masked, prospective randomized study. Enrollment criteria include subjects between ages 18 and 65 years, ASA 1-3, with good liver and renal function. All procedures were performed UMDNJ's outpatient same day surgery center by the same surgeon (NB) under retrobulbar block administered using sub-Tenon approach. Patients are randomized into group P (prop) and group D (dex). Group P receives a of 1 mg/kg of prop intravenously (IV) followed by an infusion of 25-100 ug/kg/min. Group D receives a bolus of 0.5 ug/kg IV of dex followed by an infusion of 0.2-0.7 ug/kg/hr. T-test and Mann-Whitney test were used for statistical analysis.
In the 38 patients recruited, dex provided adequate sedation, patient and surgeon satisfaction, and hemodynamic stability, with no difference in incidence of adverse effects compared to prop. The only significant parameters between groups P and D were in systolic and diastolic BP and HR in the PACU. There were not any clinically significant events that warranted the use of rescue medications for bradycardia or hypotension. No patients experience post-operative nausea or vomiting and none required hospitalization. The mean patient and surgeon satisfaction was between good and excellent in both groups.
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