Purchase this article with an account.
Jonathan L. Prenner, Daniel B. Roth, Howard F. Fine, Harold M. Wheatley, Daniel Connors; Incidence of Steroid Induced Ocular Hypertension Following Vitreoretinal Surgery With Difluprednate Versus Prednisolone Acetate. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5383.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To identify changes in intraocular pressure (IOP) after vitreoretinal surgical procedures in eyes that received either difluprednate ophthalmic emulsion 0.05% (DP) or prednisolone acetate ophthalmic suspension 1% (PA).
A retrospective chart review compared a consecutive series of 100 patients who received DP with 100 patients who received PA after vitreoretinal surgery. Data were collected for a three-month period from the time of surgery.
A significantly higher number of patients treated with DP (34%, n=34) developed increased IOP (>10mm Hg change from baseline and greater than 21) compared with those receiving PA (21%, n=21), (p=0.04). The mean maximum IOP in the DP cohort (28.0 mm Hg) was significantly higher than in the PA cohort (24.3 mm Hg), (p=0.01). Additionally, the rise in IOP from baseline was significantly higher in the DP treated cohort (9.6 mm Hg) than in the PA treated cohort (6.7 mm Hg), (p=0.02).
Eyes treated with DP after vitreoretinal surgery were at increased risk for developing clinically significant increases in IOP compared with those receiving PA.
This PDF is available to Subscribers Only