March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Changes In Functional Visual Acuity And Ocular Wavefront Aberration After Administration Of Eye Ointment
Author Affiliations & Notes
  • Takahiro Hiraoka
    Dept of Ophthalmology, University of Tsukuba, Tsukuba, Japan
  • Toshiya Yamamoto
    Dept of Ophthalmology, Ushiku Aiwa General Hospital, Ushiku, Japan
  • Fumiki Okamoto
    Dept of Ophthalmology, University of Tsukuba, Tsukuba, Japan
  • Tetsuro Oshika
    Dept of Ophthalmology, University of Tsukuba, Tsukuba, Japan
  • Footnotes
    Commercial Relationships  Takahiro Hiraoka, None; Toshiya Yamamoto, None; Fumiki Okamoto, None; Tetsuro Oshika, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 5462. doi:
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      Takahiro Hiraoka, Toshiya Yamamoto, Fumiki Okamoto, Tetsuro Oshika; Changes In Functional Visual Acuity And Ocular Wavefront Aberration After Administration Of Eye Ointment. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5462.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the influence of an eye ointment on functional visual acuity (FVA) and ocular wavefront aberration.

Methods: : In 11 healthy volunteers, visual function parameters such as FVA, visual maintenance ratios (VMR), and minimal visual acuity (minVA), were assessed by the FVA measurement system before and 2, 5, 10, 20, 30, 40, 50, 60, 90, 120, 180, 240 minutes after administration of ofloxacin eye ointment. Ocular aberration was also measured, and the root-mean-square (RMS) of second-, third-, fourth-, and total higher-order aberrations were determined. The time course of changes in each parameter was statistically analyzed by using repeated-measures analysis of variance and the Dunnett post-hoc test, and relationships between visual function and ocular aberration parameters were also analyzed by the Pearson correlation test.

Results: : FVA, VMR, and minVA showed significant deteriorations at 2-, 5-, 10-, 20-minutes after administration of eye ointment compared with the baseline values (P < 0.05). All components of ocular wavefront aberration such as second-, third-, fourth-, and total higher-order RMS significantly increased at 2- and 5-minutes after administration of eye ointment compared with the baseline values (P < 0.05). In addition, all visual function parameters were significantly correlated with blink numbers (Pearson’s correlation coefficient; r = -0.76, P = 0.017 for FVA, r = 0.79, P = 0.013 for VMR, and r = -0.62, P = 0.040 for minVA), and VMR was significantly related with changes in second-order RMS (r = -0.60, P = 0.049).

Conclusions: : Eye ointment significantly reduced visual function for at least 20 minutes. Especially, minimal visual acuity was worse than 0.155 logMAR, that is required for driving in Japan, for 3 hours after the administration. In addition, increases in lower-order aberration and reduced blink rates were associated with the degradation of visual function. However, the observed visual impairments could not be explained only by these factors.

Keywords: visual acuity • aberrations • drug toxicity/drug effects 
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