March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Central Retinal Vein Occlusion: Oct And Ferg Findings In Affected And Fellow Eyes
Author Affiliations & Notes
  • Mirella Lizzano
    Ophtalmology Policlinico S. Matteo, IRCCS POLICLINICO SAN MATTEO, Pavia, Italy
  • Giulio Ruberto
    Ophtalmology Policlinico S. Matteo, IRCCS POLICLINICO SAN MATTEO, Pavia, Italy
  • Carmine Tinelli
    Ophtalmology Policlinico S. Matteo, IRCCS POLICLINICO SAN MATTEO, Pavia, Italy
  • Patrizia Piccinini
    Ophtalmology Policlinico S. Matteo, IRCCS POLICLINICO SAN MATTEO, Pavia, Italy
  • Jessica Dispinseri
    Ophtalmology Policlinico S. Matteo, IRCCS POLICLINICO SAN MATTEO, Pavia, Italy
  • Giulio Vandelli
    Ophtalmology Policlinico S. Matteo, IRCCS POLICLINICO SAN MATTEO, Pavia, Italy
  • Paolo E. Bianchi
    Ophtalmology Policlinico S. Matteo, IRCCS POLICLINICO SAN MATTEO, Pavia, Italy
  • Footnotes
    Commercial Relationships  Mirella Lizzano, None; Giulio Ruberto, None; Carmine Tinelli, None; Patrizia Piccinini, None; Jessica Dispinseri, None; Giulio Vandelli, None; Paolo E. Bianchi, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 5696. doi:
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      Mirella Lizzano, Giulio Ruberto, Carmine Tinelli, Patrizia Piccinini, Jessica Dispinseri, Giulio Vandelli, Paolo E. Bianchi; Central Retinal Vein Occlusion: Oct And Ferg Findings In Affected And Fellow Eyes. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5696.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Macular oedema in central retinal vein occlusion (CRVO) is frequently associated with visual loss.The severity of macular edema can be evaluated either with optical coherence tomography (OCT), which provides a quantitative assessment of macular edema, or with focal electroretinogram (fERG), which allows an examination of the retinal function within the macular area. The purpose of this study is to investigate the relationship between visual acuity and morpho-functional results in macular edema in unilateral CRVO and compare these results to those of fellow eyes and of normal control subjects.

Methods: : We studied 34 patients affected by unilateral CRVO matched with normal control subjects with normal visual acuity and without any ocular disease. We established three different groups : pathologic eyes (P); fellow eyes (N), control subject (N1) and performed the ETDRS visual acuity examination, macular OCT (OCT 3 STRATUS) and f ERG via ERG dome on each group. The amplitude and latencies of a wave, b wave and the photopic negative response (PhNR), the OCT values of foveal thickness and macular volume were recorded and analysed. Differences among groups were done by mean of Kruskal-Wallis tests; correlations were evaluated with Spearman’s coefficient.

Results: : We did not find a correlation between visual acuity and OCT values in any group.The amplitude of b-wave ( r=0.43; P=0.083) and PhNR(r=0.54;P=0.06) correlate with visual acuity only in the normal control group (N1). In addition, the amplitude of b-wave is the only parameter that shows a significant statistical difference (P= 0.0008) between healthy fellow eyes (N) and normal control subjects (N1. fig 1).

Conclusions: : In this study fellow eyes exhibited a relatively high percentage of abnormal fERG, probably caused by retinal circulatory disturbance. As the b wave is generated from cells in neural layer of the retina perfused by the retinal circulation, this wave is immediately affected readily. Probably this microvascular change could precede the CRVO, and suggest a follow up not only in affected eyes but also in fellow eye

Keywords: electrophysiology: clinical • vascular occlusion/vascular occlusive disease • edema 
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