March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Correlation Of The Detection Of Blood Flow In An RPE-choroid Graft With Phase-resolved Doppler OFDI, With The Revascularization Steps Found On SD-OCT
Author Affiliations & Notes
  • Elsbeth J. Van Zeeburg
    The Rotterdam Eye Hospital, Rotterdam, The Netherlands
    Rotterdam Ophthalmic Institute, Rotterdam, The Netherlands
  • Boy Braaf
    Rotterdam Ophthalmic Institute, Rotterdam, The Netherlands
  • Matteo G. Cereda
    The Rotterdam Eye Hospital, Rotterdam, The Netherlands
  • Jan C. van Meurs
    The Rotterdam Eye Hospital, Rotterdam, The Netherlands
    Erasmus MC, Universtiy Medical Center, Rotterdam, The Netherlands
  • Johannes F. de Boer
    Rotterdam Ophthalmic Institute, Rotterdam, The Netherlands
    : Institute for Lasers, Life and Biophotonics Amsterdam, Department of Physics and Astronomy, VU University, Amsterdam, The Netherlands
  • Footnotes
    Commercial Relationships  Elsbeth J. Van Zeeburg, None; Boy Braaf, None; Matteo G. Cereda, None; Jan C. van Meurs, None; Johannes F. de Boer, OCT-Technologies (P)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 5845. doi:
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      Elsbeth J. Van Zeeburg, Boy Braaf, Matteo G. Cereda, Jan C. van Meurs, Johannes F. de Boer; Correlation Of The Detection Of Blood Flow In An RPE-choroid Graft With Phase-resolved Doppler OFDI, With The Revascularization Steps Found On SD-OCT. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5845.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To correlate the detection of blood flow in a retinal pigment epithelium (RPE) choroid graft with phase-resolved Doppler Optical Frequency Domain Imaging (Doppler-OFDI) and the revascularization steps found on commercially available Spectral Domain Optical Coherence Tomography (SD-OCT).

 
Methods:
 

Five patients with age related macular degeneration underwent an RPE choroid graft translocation. Pre- and postoperative SD-OCT scans were made, in which the thickness of the graft, number and diameter of the vessels, and thickness of the fluid under the graft were measured; in order to monitor the revascularization process of the graft. Additionally phase-resolved Doppler-OFDI (Swept-Source OCT) scans were made to directly detect the presence of flow.

 
Results:
 

SD-OCT was able to detect both the afferent and efferent vessel in growth phase in 5 out of 5 patients.Doppler-OFDI detected flow in 4 patients when SD-OCT showed the efferent vessel in growth phase. In one patient Doppler-OFDI detected flow one visit later than SD-OCT showed the efferent vessel in growth phase.

 
Conclusions:
 

Doppler-OFDI was able to confirm blood flow in a free RPE choroid graft and correlated well with the establishment of revascularization as suggested on SD-OCT.  

 
Keywords: retinal pigment epithelium • transplantation • age-related macular degeneration 
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