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Tamara J. Lee, Janine Bernardo, Christine Sonnie, George Hoppe, Jonathan E. Sears; Comparison of Neurodevelopmental Outcomes In Two Retinopathy of Prematurity (ROP) Cohorts: Standard vs. Revised Oxygen Saturation Protocol Groups. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5877.
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© ARVO (1962-2015); The Authors (2016-present)
Retinopathy of prematurity (ROP) is a leading cause of childhood blindness in the US. Compared to standard high oxygen saturation targets (>95%), revised protocols using early low targets (85-92% before 34 weeks gestational age) and late high targets (92-97% after 34 weeks gestations age) which mimics in utero conditions, induces normal retinal development while decreasing the severity and incidence of ROP. Long-term neurodevelopmental outcomes are needed to support the beneficial effect that this revised oxygen saturation protocol has on ROP prevention.
We performed a retrospective analysis of 109 infants with ROP. A revised oxygen protocol was initiated on July 31, 2006 such that 37 infants admitted to the NICU prior to this date had standard high targets and 72 infants admitted after this date had early low and late high targets. Two-tailed t-testing and chi-square testing was used to compare the primary outcome of Bayley Scales of Infant Development (BSID) score, and the secondary outcomes: rates of clinically significant developmental delay (CSDD), cerebral palsy (CP), hearing impairment, and delay without disability.
Cognitive, language, and motor BSID scores were not significantly different between the two groups (p=0.1267, 0.3481, 0.3718). Rates of CSDD, CP, hearing impairment, and delay without disability were also not significantly different (0.117, 1.000, 0.172, and 1.000).
There is no statistically significant difference in neurodevelopmental outcomes among standard vs. revised oxygen saturation protocol cohorts. This study suggests that in infants who can tolerate revised oxygen saturation protocol, ROP can be prevented without impairing neurodevelopmental outcomes.
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