March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Comparison of Neurodevelopmental Outcomes In Two Retinopathy of Prematurity (ROP) Cohorts: Standard vs. Revised Oxygen Saturation Protocol Groups
Author Affiliations & Notes
  • Tamara J. Lee
    Ophthalmology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio
  • Janine Bernardo
    Ophthalmology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio
  • Christine Sonnie
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio
  • George Hoppe
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio
  • Jonathan E. Sears
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio
  • Footnotes
    Commercial Relationships  Tamara J. Lee, None; Janine Bernardo, None; Christine Sonnie, None; George Hoppe, None; Jonathan E. Sears, None
  • Footnotes
    Support  Fight For Sight Student Fellowship
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 5877. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Tamara J. Lee, Janine Bernardo, Christine Sonnie, George Hoppe, Jonathan E. Sears; Comparison of Neurodevelopmental Outcomes In Two Retinopathy of Prematurity (ROP) Cohorts: Standard vs. Revised Oxygen Saturation Protocol Groups. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5877.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : Retinopathy of prematurity (ROP) is a leading cause of childhood blindness in the US. Compared to standard high oxygen saturation targets (>95%), revised protocols using early low targets (85-92% before 34 weeks gestational age) and late high targets (92-97% after 34 weeks gestations age) which mimics in utero conditions, induces normal retinal development while decreasing the severity and incidence of ROP. Long-term neurodevelopmental outcomes are needed to support the beneficial effect that this revised oxygen saturation protocol has on ROP prevention.

Methods: : We performed a retrospective analysis of 109 infants with ROP. A revised oxygen protocol was initiated on July 31, 2006 such that 37 infants admitted to the NICU prior to this date had standard high targets and 72 infants admitted after this date had early low and late high targets. Two-tailed t-testing and chi-square testing was used to compare the primary outcome of Bayley Scales of Infant Development (BSID) score, and the secondary outcomes: rates of clinically significant developmental delay (CSDD), cerebral palsy (CP), hearing impairment, and delay without disability.

Results: : Cognitive, language, and motor BSID scores were not significantly different between the two groups (p=0.1267, 0.3481, 0.3718). Rates of CSDD, CP, hearing impairment, and delay without disability were also not significantly different (0.117, 1.000, 0.172, and 1.000).

Conclusions: : There is no statistically significant difference in neurodevelopmental outcomes among standard vs. revised oxygen saturation protocol cohorts. This study suggests that in infants who can tolerate revised oxygen saturation protocol, ROP can be prevented without impairing neurodevelopmental outcomes.

Keywords: retinopathy of prematurity • oxygen • clinical (human) or epidemiologic studies: outcomes/complications 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×