March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Intraocular Pressure Reduction After Repeated Selective Laser Trabeculoplasty (slt)
Author Affiliations & Notes
  • Marcelo N. Ayala
    St Erik Eye Hospital, Stockholm, Sweden
  • Enping Chen
    St Erik Eye Hospital, Stockholm, Sweden
  • Footnotes
    Commercial Relationships  Marcelo N. Ayala, None; Enping Chen, None
  • Footnotes
    Support  Swedish Foundations: Ögonfonden, Capio Forskningstiftelse and Stiftelsen Olle Engkvist Byggmästare
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 5960. doi:
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      Marcelo N. Ayala, Enping Chen; Intraocular Pressure Reduction After Repeated Selective Laser Trabeculoplasty (slt). Invest. Ophthalmol. Vis. Sci. 2012;53(14):5960.

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Abstract

Purpose: : The aim of the present article was to study intraocular pressure (IOP) reduction effects when repeated selective laser trabeculoplasty (SLT) treatment was performed in the same area of the trabecular meshwork (TM) versus when the SLT treatment was performed in adjacent TM areas.

Methods: : This was a prospective randomized clinical trial for testing the IOP reduction effects of repeated SLT treatment. Included patients were patients suffering from primary open angle or pseudoexfoliation glaucoma. All patients were treated with SLT 1 in 90° between kl 3 and 6. Patients who were decided to retreat with SLT (SLT 2) were asked to participate in the study. Included patients were randomized to either SLT 2 in the same area (kl 3-6) (group 1) or in the adjacent area (between kl 6 and 9) (group 2). IOP was checked before, 2 hours, 1 month, 3 and 6 months after SLT 2 treatment. Patients who were changed in medical therapy were excluded. The authors confirm adherence to the tenets of the Declaration of Helsinki. The study was approved by the Karolinska Institute’s ethical committee (2009/1:1).

Results: : Forty patients were included in each group. Base-line characteristics: no significant difference was found among the groups regarding age (t- test, p=0.44), gender (Χ2 , p=0.14), pseudoexfoliation glaucoma (Χ2 , p=0.07), months interval between SLT 1 and SLT 2 (t-test, p=0.78), IOP before SLT 1 (t-test, p=0.78) and IOP before SLT 2 (t-test, p=0.32). Endpoint: IOP after SLT 2 treatment in both groups showed no significant difference at any of the time interval tested: 2 hours (t-test, p=0.65), 1 month (t-test, p=0.60), 3 months (t-test, p= 0.42) and 6 months (t-test, p= 0.66).

Conclusions: : Intraocular pressure reduction after SLT treatment seems not to be altered when the same part of the TM is treated.

Clinical Trial: : http://www.isrctn.org 67927615

Keywords: laser • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • intraocular pressure 
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