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Joseph A. Donnelly, Elaine Miglino, Lawrence F. Jindra; The Effectiveness of Selective Laser Trabeculoplasty on Eyes of Different Corneal Thicknesses. Invest. Ophthalmol. Vis. Sci. 2012;53(14):5961.
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To examine the effect of corneal thickness on Selective Laser Trabeculoplasty (SLT), as primary therapy, to decrease intraocular pressure (IOP) in patients with glaucoma.
Retrospective chart review was performed on 1597 eyes from a continuous case series of 3777 eyes treated with SLT over 10 years. Eyes were selected which had been treated with SLT as primary therapy and were further subdivided by corneal thickness. Two-tailed paired t-test was used to compare maximum pre- and average post- procedure IOP.
Mean decrease in raw IOP for the entire population was 32.4%. IOP was corrected, using correction factors from Ehlers, et. al., then substratified by pachymetry, after which mean decrease in IOP was calculated for each subgroup. For corneae with thicknesses (µm) of ≤445 ,446-465, 466-475, 476-485, 486-505, 506-515, 516-535, 536-554, 555-574, 575-584, 585-594, 595-614, 615-624, 625-644, and, ≥645; mean decreases in IOP(%) were 19.6, 29.3, 33.4, 25.2, 29.5, 27.3, 28.7, 32.7, 32.9, 36.3, 38.5, 38.7, 40.5, 47.0, and 52.6 percent, respectively. Increasing relative decrease in IOP was noted with increasing corneal thickness (p<.01).
In this large, long-term clinical series, there was an effect of corneal thickness on Selective Laser Trabeculoplasty as primary therapy, resulting in increasingly greater relative decrease in intraocular pressure in eyes with increasingly greater central corneal thickness.
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