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Jaime D. Martinez, Anat Galor, Victor L. Perez, Carol L. Karp, Sonia H. Yoo, Eduardo C. Alfonso; Endothelial Graft Failure after Contralateral Autologous Corneal Transplantation. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6047.
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© ARVO (1962-2015); The Authors (2016-present)
To report on outcomes after contralateral autologous penetrating keratoplasty (APK)
We report on 5 patients who underwent contralateral APK. The median patient age at the time of surgery was 67 years (range, 58-88 years); 4 patients were male and 1 female, 1 patient was white and 4 black. The surgery was uneventful in all cases and no operative or immediate post-operative complications occurred in either eye. Follow-up time ranged from 18-54 months (mean, 34.6 months; median, 20 months). During this time, 4 of the autologous grafts failed due to endothelial attenuation as opposed to none of the 5 allogeneic grafts in the donor eye. Identified risk factors for failure in the autologous eyes included the presence of a glaucoma tube (5/5), previous graft failure (4/5) and anterior synechiae in (2/5).
This study is the first to describe graft failure due to slow endothelial attenuation after APK. This study underscores the importance of non-immunologic factors in endothelial cell loss after corneal transplant surgery and highlights the need for further research to understand and modulate endothelial loss.
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