Purchase this article with an account.
Bernardo M. Cavalcanti, Andrea Cruzat, Yureeda Qazi, Neda Baniasadi, Monique Trinidad, Amy Watts, Douglas Critser, Charles Leahy, Christine W. Sindt, Pedram Hamrah; Contact Lens/Contact Lens solution Combinations Determine the Inflammatory Changes on the Ocular Surface: A Laser In Vivo Confocal Microscopy Study. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6112.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To assess the subclinical immune responses to various contact lenses (CL) and CL solutions in naive CL wearers.
Multicenter, randomized, double-blinded, clinical trial. Sixty-five naïve CL wearers (130 eyes), fitted with silicone hydrogel CL (PureVision® [PV]; Oasys® [OA]; Biofinity® [BF]), were enrolled into one of 3 CL solution groups (OPTI-FREE RepleniSH® (OF, n=21); Clear Care® (CC, n=21); ReNu MultiPlus® (RM, n=23). Corneal, limbal, and conjunctival staining, ocular injection, as well as laser in vivo confocal microscopy (IVCM; HRT3/RCM) of the central and peripheral corneal quadrants were performed at baseline and weeks 1 and 6 post-CL wear. Three masked observers analyzed the images for dendritic cell (DC) and non-dendritic inflammatory cell (IC) density.
Increased ocular surface staining, but minimal ocular injection was observed in all groups. Conjunctival staining correlated to peripheral DC density (r>0.40 for all quadrants). RM demonstrated significantly increased staining for all conjunctival, limbal and cornea areas, correlating with highest increase in DC density in central cornea (58%), nasal (26%) and temporal (24%) quadrants at 6 weeks, as compared to OF and CC (p<0.05 between groups). Comparison of CL types showed significantly increased limbal and corneal staining for OA (p<0.05) and corneal staining with PV (p<0.04), but minimal staining with BF, with OA demonstrating highest increase in total DC (27%) as compared to PV (13%) and BF (12%) (p<0.05 between groups). Surprisingly, each CL and CL solution demonstrated combinations with minimal surface staining and no significant increase in DC as well as combinations with significant increase staining, with increase in peripheral DC.
IVCM revealed increased immune cell infiltration in all groups after CL wear as early as 1 week, while corneal and conjunctival staining were detected later at 6 weeks. While our data demonstrates that increased ocular surface staining and immune cell density are both due to CL and CL solutions, proper combination will both prevent or worsen staining and subclinical increase in immune cells.
Clinical Trial: :
This PDF is available to Subscribers Only