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Jose Manuel Gonzalez-Meijome, Ana Carla da Silva, Daniela Lopes-Ferreira, Helena Neves, Antonio Queiros Pereira; Clinical Performance and "ex-vivo" Dehydration of Silicone Hydrogel Contact Lenses with Two New Multipurpose Solutions. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6120.
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To evaluate the potential benefits of two novel multipurpose solutions (MPS) Complete RevitaLens® and Biotrue in preventing silicone hydrogel contact lens dehydration and the potential impact of lower dehydration in higher subjective comfort rates and better optical quality.
This was a prospective, double-blind, bilateral and randomized study. Twenty-five neophytes wore Air Optix Aqua (Ciba Vision, Duluth, GA) for 1 month. They used one MPS solutions in one eye and the other MPS in the fellow eye in a random and double-masked way. After dispensing patients were evaluated after 2 and 10 hours of lens wear in the first day and after 2 and 10 hours of lens wear after 30 days. Tear film analysis with Tearscope Plus (Keeler, UK) and whole eye aberrations.
Lenses dehydrated to a similar extent regardless of the solution being used. There were no significant changes in the optical quality of the eye during the month of duration of the study compared to baseline or between eyes using either MPS. NIBUT data showed a drop in tear stability from baseline at the end of day 1 and day 30 with both solutions. Burning sensation at insertion was significantly higher at 1 month visit compared to day 1 visit for Biotrue (p<0.05) while end-of-day dryness worsen similarly with both solutions after one month. However, overall satisfaction did not change significantly over the month of lens wear despite a drop below 8 out of 10 rating for Biotrue.
Both MPS solutions evaluated showed a good performance regarding objective measures of dehydration, tear stability and subjective performance when combined with a silicone hydrogel contact lens.
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