March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Comparison of Changes in Intraocular Pressure, Anterior Chamber Width, Lens Vault, and Iridocorneal Angle Between Asian and Caucasian After Phacoemulsification
Author Affiliations & Notes
  • Roland Y. Lee
    Ophthalmology, University of California, San Francisco, San Francisco, California
  • Toshimitsu Kasuga
    Ophthalmology, University of California, San Francisco, San Francisco, California
  • Guofu Huang
    Ophthalmology, University of California, San Francisco, San Francisco, California
  • Eduardo Gonzalez
    Ophthalmology, University of California, San Francisco, San Francisco, California
  • Satasuk Joy Bhosai
    Ophthalmology, University of California, San Francisco, San Francisco, California
  • Sophia Y. Wang
    Ophthalmology, University of California, San Francisco, San Francisco, California
  • Qi N. Cui
    Ophthalmology, University of California, San Francisco, San Francisco, California
  • Mingguang He
    Ophthalmology, University of California, San Francisco, San Francisco, California
  • Shan C. Lin
    Ophthalmology, University of California, San Francisco, San Francisco, California
  • Footnotes
    Commercial Relationships  Roland Y. Lee, None; Toshimitsu Kasuga, None; Guofu Huang, None; Eduardo Gonzalez, None; Satasuk Joy Bhosai, None; Sophia Y. Wang, None; Qi N. Cui, None; Mingguang He, None; Shan C. Lin, Consultant for Alcon and Allergan (C)
  • Footnotes
    Support  Research to Prevent Blindness, NIH-NEI EY002162 – Core Grant for Vision Research, and That Man May See, Inc.
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6384. doi:
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      Roland Y. Lee, Toshimitsu Kasuga, Guofu Huang, Eduardo Gonzalez, Satasuk Joy Bhosai, Sophia Y. Wang, Qi N. Cui, Mingguang He, Shan C. Lin; Comparison of Changes in Intraocular Pressure, Anterior Chamber Width, Lens Vault, and Iridocorneal Angle Between Asian and Caucasian After Phacoemulsification. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6384.

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Abstract

Purpose: : To determine the association of ethnicity with intraocular pressure reduction after phacoemulsification.

Methods: : In this prospective study, 74 Asian and 32 Caucasian subjects underwent phacoemulsification with foldable lens implantation for cataract. Anterior segment optical coherence tomography (ASOCT) scans under dark conditions and intraocular pressure (IOP) measurements by Goldmann applanation tonometry were obtained preoperatively and at 10 days and 1, 3, and 6 months after cataract surgery. From the ASOCT images, the Zhongshan Angle Assessment Program was used to calculate the anterior chamber width (ACW), angle opening distance at 500mm anterior to the scleral spur (AOD500), and lens vault. Paired t-tests were used to calculate significant difference in measurements between preoperative and postoperative time points. Linear regression analysis, adjusting for ACW, AOD500, lens vault, age, and gender, was used to determine the association between the percent change in IOP reduction and ethnicity.

Results: : At 3 months after cataract surgery, paired t-tests showed significance difference in AOD500, lens vault, and IOP. AOD500 increased significantly from 0.262±0.124 to 0.458±0.152 mm (p<0.001), lens vault decreased significantly from 672.710±379.035 to -279.385±1791.644μm (p<0.001), and IOP decreased significantly from 15.650±4.373 to 12.190±3.311 mmHg (p<0.001) following cataract surgery. After adjusting for ACW, AOD500, lens vault, age, and gender, regression analysis found the association between percent change in IOP reduction and ethnicity to be insignificant (p=0.617). Linear regression analysis found a borderline significant positive correlation between percent change in IOP reduction and lens vault (p=0.051).

Conclusions: : Ethnicity may not be a reliable predicator for IOP reduction after cataract surgery.

Keywords: intraocular pressure • imaging/image analysis: clinical • cataract 
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