March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Effect of Prophylactic Nonsteroidal Anti-Inflammatory Drugs on Pseudophakic Cystoid Macular Edema in a Series of Patients on the Wills Eye Cataract and Primary Eye Care Service
Author Affiliations & Notes
  • Fatima K. Ahmad
    Wills Eye Institute, Philadelphia, Pennsylvania
  • Brad Feldman
    Cornea Service,
    Wills Eye Institute, Philadelphia, Pennsylvania
  • Lisa A. Hark
    Department of Research,
    Wills Eye Institute, Philadelphia, Pennsylvania
  • Sana Haq
    Department of Research,
    Wills Eye Institute, Philadelphia, Pennsylvania
  • Brianna E. Kenney
    Department of Research,
    Wills Eye Institute, Philadelphia, Pennsylvania
  • Catherine E. Callinan
    Department of Research,
    Wills Eye Institute, Philadelphia, Pennsylvania
  • Yang Dai
    Jefferson Medical College, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships  Fatima K. Ahmad, None; Brad Feldman, None; Lisa A. Hark, None; Sana Haq, None; Brianna E. Kenney, None; Catherine E. Callinan, None; Yang Dai, None
  • Footnotes
    Support  Wills Eye Innovation Grant
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6691. doi:
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      Fatima K. Ahmad, Brad Feldman, Lisa A. Hark, Sana Haq, Brianna E. Kenney, Catherine E. Callinan, Yang Dai; Effect of Prophylactic Nonsteroidal Anti-Inflammatory Drugs on Pseudophakic Cystoid Macular Edema in a Series of Patients on the Wills Eye Cataract and Primary Eye Care Service. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6691.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To determine if the use of prophylactic topical nonsteroidal anti-inflammatory drugs (NSAIDs) has decreased the rate of development of cystoid macular edema (CME) following cataract surgery.

 
Methods:
 

Retrospective review of a cohort of patients on the Wills Eye resident cataract service who underwent cataract surgery between 2007 and 2010. Patients were excluded if there was less than 28 days of follow-up after surgery and preexisting macular edema. Data collection included patient demographics, systemic and ocular comorbidities, topical medication use, surgical complications, Snellen best corrected visual acuities (BCVA) for up to one year postoperatively, and diagnosis and treatment of CME.

 
Results:
 

A total of 925 operated eyes of 700 patients were reviewed. Twelve patients had preoperative macular edema and 33 patients were excluded because of less than 28 days of follow-up. In patients meeting inclusion criteria, 234 eyes (27%) did not receive perioperative NSAID, while 648 eyes (73%) did receive an NSAID. Twenty-nine patients developed pseudophakic CME (3.3%). Rates of CME in the two subgroups were 3.2% and 3.4% respectively (p=0.55).

 
Conclusions:
 

In this patient population, there was not a statistically significant decrease in rate of CME in patients who received NSAIDs. Prophylactic use of topical NSAIDs may be reserved for use in patients who are at higher risk of developing CME, and may not be cost-effective for patients undergoing routine cataract surgery.

 
Keywords: cataract • macula/fovea • immunomodulation/immunoregulation 
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