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Amani S. Albakri, Eman Al-Shahwan, Sawsan R. Nowilaty; Correlation Of Retinitis Pigmentosa Disease Stage With Orbital Color Doppler Imaging. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6846.
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To prospectively explore if disease stage in retinitis pigmentosa (RP) correlates with retinal and/or choroidal blood flow velocities measured by orbital color Doppler imaging.
Twenty nine patients with RP (age 11-67years, mean 34) were prospectively evaluated with 1) standardized clinical staging of the fundus guided by photographic templates of 4 parameters (degree of optic disc pallor, degree of retinal vascular attenuation, site of intraretinal pigmentation and amount of intraretinal pigmentation); 2) standardized orbital color Doppler imaging (CDI) of the ophthalmic artery, central retinal artery, posterior ciliary arteries and central retinal vein; 3) standardized Goldmann visual fields and 4) standardized full-field electroretinography (ERG). Ten age-matched controls without systemic vascular or ocular disease underwent standardized CDI for comparison.
Peak-systolic and end-diastolic velocities in the central retinal artery, posterior ciliary arteries and maximal and minimal velocities in the central retinal vein were consistently and significantly lower in RP patients than in controls (p<0.001). Furthermore, the central retinal artery peak-systolic velocity correlated inversely with advancing clinical stage of RP (r -.367, p 0.005), greater disc pallor (r -.032, p 0.015), greater retinal vascular attenuation (r-0.47,p<0.001), more widespread pigmentation than the midperipheral retina alone (r -0.32, p 0.016), smaller remaining central visual field (r -0.53, p < 0.001) and lower ERG amplitudes (r .354, p 0.006). The central retinal artery was the vessel which displayed the most significant changes in velocity as RP progressed, followed by the central retinal vein. The ophthalmic and ciliary arteries’ velocities showed no significant correlation with the stage of RP.
Retinal arterial velocities are decreased in eyes with retinitis pigmentosa. With disease progression, central retinal arterial velocities further decrease. These findings may add to the characterization of retinitis pigmentosa and to a better understanding of the pathogenesis of the disease and its progression.
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