Purchase this article with an account.
Eiichi Sato, Taiji Nagaoka, Atsushi Takahashi, Kenji Sogawa, Tsuneaki Omae, Seigo Nakabayashi, Akitoshi Yoshida; Effect of Aging on the Retinal Arterial Stiffness in Healthy Subjects. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6852.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
The pulsatility ratio (PR) is an index of vessel rigidity. Although arterial stiffness is thought to increase with age, it is unclear how the PR in the retinal artery changes with age. The purpose of this study was to evaluate the effect of aging on the PR in the retinal artery in healthy individuals.
One hundred eight healthy subjects (57 men; 51 women; age range, 20~77 years) were included. Subjects were divided into the following age groups (in years): 20s, 30s, 40s, 50s, 60s, and 70s. Using a retinal laser Doppler system (Canon Laser Blood Flowmeter, Model CLBF 100, Canon Inc, Tokyo, Japan), the vessel diameter and blood velocity were measured and the retinal blood flow (RBF) was calculated in the superior temporal retinal artery. The PR was calculated from the blood velocity profile. The PR is expressed as Vmax/Vmin, where Vmax is the peak systolic velocity during systole and Vmin is the end diastolic velocity.
No significant differences were seen between the groups in blood pressure, vessel diameter, blood velocity, or RBF. The PRs of individuals in their 60s (3.79 ± 0.88, mean ± standard deviation) and 70s (5.14 ± 1.48) increased markedly and were significantly (P < 0.001) higher than that of those in their 20s (2.67 ± 0.35).
Aging did not significantly affect diameter, velocity, or RBF in healthy individuals. However, the PR markedly increased in individuals over 60 years of age, possibly indicating that the retinal arterial stiffness might progress after 60 years of age.
This PDF is available to Subscribers Only