March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Effect of Aging on the Retinal Arterial Stiffness in Healthy Subjects
Author Affiliations & Notes
  • Eiichi Sato
    Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
  • Taiji Nagaoka
    Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
  • Atsushi Takahashi
    Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
  • Kenji Sogawa
    Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
  • Tsuneaki Omae
    Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
  • Seigo Nakabayashi
    Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
  • Akitoshi Yoshida
    Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
  • Footnotes
    Commercial Relationships  Eiichi Sato, None; Taiji Nagaoka, None; Atsushi Takahashi, None; Kenji Sogawa, None; Tsuneaki Omae, None; Seigo Nakabayashi, None; Akitoshi Yoshida, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6852. doi:
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      Eiichi Sato, Taiji Nagaoka, Atsushi Takahashi, Kenji Sogawa, Tsuneaki Omae, Seigo Nakabayashi, Akitoshi Yoshida; Effect of Aging on the Retinal Arterial Stiffness in Healthy Subjects. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6852.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : The pulsatility ratio (PR) is an index of vessel rigidity. Although arterial stiffness is thought to increase with age, it is unclear how the PR in the retinal artery changes with age. The purpose of this study was to evaluate the effect of aging on the PR in the retinal artery in healthy individuals.

Methods: : One hundred eight healthy subjects (57 men; 51 women; age range, 20~77 years) were included. Subjects were divided into the following age groups (in years): 20s, 30s, 40s, 50s, 60s, and 70s. Using a retinal laser Doppler system (Canon Laser Blood Flowmeter, Model CLBF 100, Canon Inc, Tokyo, Japan), the vessel diameter and blood velocity were measured and the retinal blood flow (RBF) was calculated in the superior temporal retinal artery. The PR was calculated from the blood velocity profile. The PR is expressed as Vmax/Vmin, where Vmax is the peak systolic velocity during systole and Vmin is the end diastolic velocity.

Results: : No significant differences were seen between the groups in blood pressure, vessel diameter, blood velocity, or RBF. The PRs of individuals in their 60s (3.79 ± 0.88, mean ± standard deviation) and 70s (5.14 ± 1.48) increased markedly and were significantly (P < 0.001) higher than that of those in their 20s (2.67 ± 0.35).

Conclusions: : Aging did not significantly affect diameter, velocity, or RBF in healthy individuals. However, the PR markedly increased in individuals over 60 years of age, possibly indicating that the retinal arterial stiffness might progress after 60 years of age.

Keywords: clinical (human) or epidemiologic studies: prevalence/incidence • aging 
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