March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Patients blinded by outer retinal dystrophies are able to perceive simultaneous colors using the Argus® II Retinal Prosthesis System
Author Affiliations & Notes
  • Paulo E. Stanga
    Manchester Royal Eye Hospital and University of Manchester, Manchester, United Kingdom
    Manchester Biomedical Research Centre, Manchester, United Kingdom
  • Jose A. Sahel, Jr.
    UMR-S 968, Institut de la Vision, Paris, France
  • Lyndon daCruz
    Moorfields Eye Hospital, London, United Kingdom
  • Farhad Hafezi
    Ophthalmology, Geneva University Hospitals, Geneva, Switzerland
  • Francesco Merlini
    Second Sight Medical Products (Switzerland), Lausanne, Switzerland
  • Brian Coley
    Second Sight Medical Products (Switzerland), Lausanne, Switzerland
  • Robert J. Greenberg
    Second Sight Medical Products, Inc, Sylmar, California
  • Argus II Study Group
    Manchester Royal Eye Hospital and University of Manchester, Manchester, United Kingdom
  • Footnotes
    Commercial Relationships  Paulo E. Stanga, Second Sight Medical Products, Inc. (F); Jose A. Sahel, Jr., Second Sight Medical Products, Inc. (F); Lyndon daCruz, Second Sight Medical Products, Inc. (F); Farhad Hafezi, Second Sight Medical Products (F); Francesco Merlini, Second Sight Medical Products, Inc (E); Brian Coley, Second Sight Medical Products, Inc (E); Robert J. Greenberg, Second Sight Medical Products, Inc (E)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 6952. doi:
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      Paulo E. Stanga, Jose A. Sahel, Jr., Lyndon daCruz, Farhad Hafezi, Francesco Merlini, Brian Coley, Robert J. Greenberg, Argus II Study Group; Patients blinded by outer retinal dystrophies are able to perceive simultaneous colors using the Argus® II Retinal Prosthesis System. Invest. Ophthalmol. Vis. Sci. 2012;53(14):6952.

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      © 2016 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose: : To test if patients blinded by outer retinal dystrophies can consistently perceive different colored percepts at the same time with the Argus II Retinal Prosthesis System.

Methods: : Four blind subjects with retinitis pigmentosa (bare light perception or worse vision in both eyes, functional ganglion cells and intact optic nerve, confirmed history of useful form vision), fitted with the Argus II retinal prosthesis were tested. Different pairs of electrodes were stimulated simultaneously with trains of cathodic-anodic pulses with different parameters (12 trials per pairs of electrodes). The electrodes selection was based on the threshold values and the position of the electrodes. Subjects reported the color(s) they perceived after each stimulation.

Results: : Seven different combinations of colors were perceived by the subjects (gray-white, yellow-gray, orange-white, white-blue, brown-white, yellow-white, yellow-blue). Three subjects were able to perceive two different colors at the same time using different stimulation parameters. One subject was able to perceive two different colors but not simultaneously. Different colors can be stimulated from the same electrode but with different parameters.

Conclusions: : Three blind subjects fitted with the Argus II Retinal Prosthesis System were able to perceive different colored flashes at the same time. This is the first time that a retinal prosthetic device has been shown to allow a group of blind patients to perceive two different colors simultaneously. These data, as well as data from future studies, could allow us to provide a rudimentary version of color vision to blind patients.

Clinical Trial: : http://www.clinicaltrials.gov NCT00407602

Keywords: color vision • retinitis • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials 
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