April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Detection of Photoreceptor Disruption after Commotio Retinae using Adaptive Optics Scanning Laser Ophthalmoscopy
Author Affiliations & Notes
  • Kimberly E. Stepien
    Ophthalmology,
    Medical College of Wisconsin, Milwaukee, Wisconsin
  • Wanda M. Martinez
    Ophthalmology,
    Medical College of Wisconsin, Milwaukee, Wisconsin
  • Adam M. Dubis
    Department of Cell Biology, Neurobiology and Anatomy,
    Medical College of Wisconsin, Milwaukee, Wisconsin
  • Robert F. Cooper
    Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin
  • Alfredo Dubra
    Flaum Eye Institute, University of Rochester, Rochester, New York
  • Joseph Carroll
    Ophthalmology,
    Medical College of Wisconsin, Milwaukee, Wisconsin
  • Footnotes
    Commercial Relationships  Kimberly E. Stepien, None; Wanda M. Martinez, None; Adam M. Dubis, None; Robert F. Cooper, None; Alfredo Dubra, None; Joseph Carroll, None
  • Footnotes
    Support  CTSI-MCW,CTSA Grant UL1 RR 031973, E. Matilda Ziegler Foundation for the Blind, RD and Linda Peters Foundation, Research to Prevent Blindness, and NIH (EY017607, EY001931, EY014537).
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6657. doi:
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      Kimberly E. Stepien, Wanda M. Martinez, Adam M. Dubis, Robert F. Cooper, Alfredo Dubra, Joseph Carroll; Detection of Photoreceptor Disruption after Commotio Retinae using Adaptive Optics Scanning Laser Ophthalmoscopy. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6657.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To present adaptive optics scanning laser ophthalmoscopy (AOSLO) images of photoreceptor disruption as a result of commotio retinae.

 
Methods:
 

A 41 year-old male with a 4 year history of a stable, well defined, crescent-shaped scotoma after an industrial accident in which he experienced significant head trauma underwent complete ophthalmic exam, fluorescein angiogram (FA), spectral domain optical coherence tomography (SD-OCT), Humphrey visual field (HVF) testing, and microperimetry. Newly developed (Jan 2011) confocal AOSLO imaging was also performed.

 
Results:
 

Clinical exam, FA, SD-OCT and 24-2 HVF testing detected no abnormalities. Central non-specific changes were seen on 10-2 HVF. AOSLO imaging revealed a crescent-shaped area of cone photoreceptor mosaic disruption just temporal to the fovea (Figure 1. Fovea - white rectangle; Photoreceptor disruption - darker area temporal to fovea) indicating a compromise in photoreceptor structural integrity within this area. Microperimetry confirmed corresponding functional visual loss in this region.

 
Conclusions:
 

AOSLO imaging revealed a well-defined area of photoreceptor mosaic disruption from prior commotio retinae injury not detected by clinical exam or other imaging. AOSLO may be useful in the detection and better understanding photoreceptor pathology in the setting of eye trauma or severe head/body trauma, including traumatic brain injury.  

 
Keywords: trauma • retina • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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