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T. Agawa, Y. Yamauchi, T. Mizusawa, A. Nakamura, M. Nomura, Y. Ishii, S. Otsubo, K. Aizawa, T. Sota, H. Goto; Can Infrared Spectrum Imaging Diagnose Polypoidal Choroidal Vasculopathy Without Indocyanine Green Angiography?. Invest. Ophthalmol. Vis. Sci. 2009;50(13):314.
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© ARVO (1962-2015); The Authors (2016-present)
In a recent tend, optical coherence tomography plays an important role of clinical evaluation of polypoidal choroidal vasculopathy (PCV). However, indocyanine green angiography (IA) is still powerful tool to diagnose PCV especially at initial diagnosis. Nevertheless, IA requires a burden, intravenous injection. Thus, a new diagnostic method of PCV using infrared spectrum imaging (ISI) without intravenous injection was estimated in this study.
Nine eyes of 9 patients suspected PCV clinically at initial attendance to Tokyo Medical University Hospital were included in this study. Color fundus photograph, IA and ISI was performed. The device of ISI, customized commercial fundus camera (VX-10i; Kowa, Nagoya), applied hyper spectrum (720-950 nm) imaging technology. The system allows 5 seconds to obtain the data of a 50-degree field at the surface. To create an image of blood speed in choroidal vessels, principal component of acquired spectral data was analyzed. Moving-average method of the image was hired to reduce the artifact. The light and shade in the spectrum imaging means the speed of circulation of the choroid. When speed of choroidal circulaton is high, domain is supposed to be depicted brightly. Spectrum image was superimposed on late phase IA image to estimate the capability of ISI to detect choroidal polyp.
In all of 9 patients, orange elevated lesion in color fundus photograph and hyper fluorescein of PCV in IA was identified. Blight domains in the style of PCV, depicted in ISI, accorded with hyper fluorescein of PCV in IA in 7 of 9 patients. However, in those 7 patients some of hyper fluorescein of PCV in IA was not depicted as blight domains in ISI.
Even though ISI didn’t show identically same image in IA in patients with PCV at the present time, ISI is capable to diagnose PCV with primary version.
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