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Y. Kawakami, H. Sasaki, F. Jonasson, Y. Sakamoto, M. Kojima, R. Honda, K. Sasaki; Five and Twelve Year Incidence of Cataract Surgery in Patients With Pseudoexfoliation Syndrome Reykjavik Eye Study. Invest. Ophthalmol. Vis. Sci. 2009;50(13):501.
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© ARVO (1962-2015); The Authors (2016-present)
Persons with pseudoexfoliation syndrome (PEX) have been reported to have high prevalence of cataract, however, reports of PEX being associated with more advanced cataract that requires surgery are conflicting. The purpose was to establish the 5 and 12-year incidence of cataract surgery, comparing PEX(+) group and PEX(-) group at 1996.
In 1996 we examined a random sample of citizens of Reykjavik 50 years and older, equal percentage for each year of birth and both sexes. Altogether 1045 persons were examined a response rate of 75%. Examination included maximal dilatation of pupils and examination on the slitlamp and typing and grading of cataract as well as Scheimpflug photography. These examinations were repeated at 5 (2001) and 12 (2008) years respectively. At follow-up visits we examined 846 and 573 persons i.e. 88% and 71.4% of survivors, respectively. We calculated the rate of cataract surgery at 2001 and 2008 according to presence or absence of PEX in 1996 and surgery rate by right eyes.
Evaluable right eyes were 993 in 1996, 808 in 2001 and 560 in 2008. Prevalence of PEX was 9.0% (89 right eyes) in 1996, 11.0% (89 right eyes) in 2001 and 13.0% (73 right eyes) in 2008. The rate of cataract surgery in PEX(+) group and PEX(-) group were 9.6% vs. 3.0% in 2001 (p<0.05) and 48.3% vs. 11.2% in 2008 (p<0.001). The rates by age groups in 2001 were 0% vs.1.3% in the age groups 50-59 years, 9.1% vs.1.3%(p<0.01)in the age group 60-69 years and 8.0% vs. 7.9% in age group 70’s at baseline. In 2008, the rates were 20.0% vs. 4.7% in 50’s, 38.5% vs.10.2% (p<0.01) in 60’s and 70.0% vs. 45.0% in 80’s. Odds ratio, adjusted for age and sex, for cataract surgery in right eye with PEX were 1.595 (95%CI 0.561-4.535) in 2001 and 2.224(95%CI 1.146-4.315)in 2008.
After adjusting for age and sex , right eyes with PEX at baseline had significantly increased risk of having cataract surgery at 5 and 12 years as compared with right eyes without PEX at baseline, even.
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