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T. Y. Wong, W. T. Tay, P. Mitchell, A. G. Tan, P. C. Fong, N. Sangeetha, M. Sandar, T. Aung, J. J. Wang, S. M. Saw; Prevalence of and Risk Factors for Age-Related Cataract: The Singapore Malay Eye Study. Invest. Ophthalmol. Vis. Sci. 2009;50(13):505.
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To describe the prevalence of and risk factors for age-related cataract in the older Malay population in Singapore
A population-based cross-sectional study of 3,280 (78.7% response) Singaporean Malay adults aged 40 to 80 years. Digital slit-lamp and retroillumination lens photographs were taken from both eyes and graded for age-related nuclear, cortical and posterior subcapsular (PSC) cataract following the Wisconsin grading system. Information on medical and lifestyle factors was collected via a questionnaire and a standardized clinical eye examination was performed.
3030 (92.4%) of participants had gradable lens photographs. The overall age-adjusted prevalence of any cataract or cataract surgery was 29.8% (95% CI 28.1-31.6), increasing from from 6.3%, 28.3%, 69.6%, 92.8% in those 40-49 years, 50-59 years, 60-69 years and 70-80 years, respectively (p trend<0.001). Age-adjusted prevalence rates for nuclear, cortical and PSC cataract were 10.5% (95% CI 9.6-11.5), 19.5% (95% CI 18.1-21.0) and 9.0% (95% CI 8.1-10.1), respectively. In multivariate adjusted analyses, independent risk factors for nuclear cataract included older age, female gender, current cigarette smoking, higher systolic blood pressure and HDL cholesterol; for cortical and PSC cataract, independent risk factors were older age, female gender, greater body mass index and higher HbA1c.
One in three older Malay adults had cataract in Singapore. Cortical cataract was the most common subtype. Age-related cataract was associated with modifiable cardiovascular and metabolic risk factors.
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