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V. Cosatto, A. Wainwright, E. Rochtchina, Y. P. Zhang, G. Liew, W. Hsu, M. L. Lee, P. Mitchell, T. Y. Wong, J. J. Wang; Correlation Between Right and Left Eyes in the Measurement of Retinal Vascular Fractal Dimension in an Older Population. Invest. Ophthalmol. Vis. Sci. 2009;50(13):99.
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© ARVO (1962-2015); The Authors (2016-present)
Retinal vessel fractal dimension (Df) is a global measure of density in the retinal vasculature. Recent research suggests that this measurement may indicate subtle retinal microvascular changes associated with different ocular and systemic conditions. We assessed the correlation between Df measurements of the left and right eyes of the same person, using Blue Mountains Eye Study (BMES) data.
A random subsample of 300 participants (600 eyes) was selected from the baseline BMES survey (1992-4). IRIS-Fractal (version 1.4) was used to measure Df, by outlining a skeletonised line tracing of the retinal vascular network from the original digitised image. Intraclass correlation coefficients (ICC) were used to assess intergrader reproducibility between graders on 300 right eye images. The mean Df of right and left eyes was compared using Student’s paired t-test, and the similarity in Df between right and left eyes was assessed using Pearson correlation coefficients (r).
In this subsample, 63% were female and the mean (SD) age was 63.8 (8.4) years. Intergrader reliability was high (ICC 0.90; 95% confidence interval, CI, 0.88-0.92). There was no significant difference in Df between right (mean 1.449 ± 0.018 SD) and left (1.450 ± 0.017) eyes (p=0.40). The correlation of Df between right and left eyes was moderate when graded by the same grader (r= 0.56; p< 0001) or by two different graders (r=0.55; p<0.0001). Age did not affect the right and left correlation of Df as the correlation was similar between persons aged <65 years (r=0.50) and those aged ≥65 years (r=0.55).
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