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A. I. Kim, K. A. Townsend, J. Baird, G. Wollstein, R. A. Bilonick, H. Ishikawa, L. Kagemann, J. S. Duker, J. G. Fujimoto, J. S. Schuman; Reproducibility of Spectral-Domain Optical Coherence Tomography (SD-OCT) Measurements. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1086.
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We previously reported the reproducibility of SD-OCT (RTVue, Optovue, Fremont, CA) using an early commercial version of the segmentation software. In this study we examine the effect of a software revision on reproducibility of retinal nerve fiber layer (RNFL) and foveal thickness measurements, and cup to disc ratio.
Fifteen healthy subjects (16 eyes) and 12 glaucoma subjects (17 eyes) were scanned with time-domain OCT (TD-OCT; Stratus OCT, Carl Zeiss Meditec, Dublin, CA) using the fast RNFL, fast macula and fast optic disc scans, and with RTVue (software version 3.0) using the NHM4, RNFL 3.45 mm, and MM5 scans. All subjects had 3 qualified scans from each device in each of 3 (healthy) or 2 visits (glaucoma) within 2 months. Mixed effect models were used to calculate intravisit reproducibility as standard deviation (SD) and intraclass correlation coefficients (ICC).
RTVue RNFL measurements reported in the table were obtained from NHM4 scan. Using the RNFL 3.45 scan, the SD was 2.562 µm. RTVue had statistically significantly better reproducibility than Stratus in all parameters except for the overall fovea.
Software modification can markedly improve the reproducibility of SD-OCT up to a level where it exceeds the reproducibility of TD-OCT.
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