April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Retinal Nerve Fiber Layer Thickness in Normals Measured by Spectral Domain Optical Coherence Tomography
Author Affiliations & Notes
  • D. Baleanu
    Ophthalmology, University Hospital Erlangen, Erlangen, Germany
  • R. P. Tornow
    Ophthalmology, University Hospital Erlangen, Erlangen, Germany
  • F. K. Horn
    Ophthalmology, University Hospital Erlangen, Erlangen, Germany
  • R. Laemmer
    Ophthalmology, University Hospital Erlangen, Erlangen, Germany
  • F. E. Kruse
    Ophthalmology, University Hospital Erlangen, Erlangen, Germany
  • C. Y. Mardin
    Ophthalmology, University Hospital Erlangen, Erlangen, Germany
  • Footnotes
    Commercial Relationships  D. Baleanu, None; R.P. Tornow, None; F.K. Horn, None; R. Laemmer, None; F.E. Kruse, None; C.Y. Mardin, None.
  • Footnotes
    Support  DFG (SFB 539)
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1094. doi:
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      D. Baleanu, R. P. Tornow, F. K. Horn, R. Laemmer, F. E. Kruse, C. Y. Mardin; Retinal Nerve Fiber Layer Thickness in Normals Measured by Spectral Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1094.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine normal values for peripapillary retinal nerve fiber layer thickness (RNFL) measured by spectral domain Optical Coherence Tomography (SD-OCT) in healthy adult Caucasian subjects and examine RNFL-age relationship.

Methods: : The peripapillary RNFL of 170 healthy subjects, 96 males and 74 females, age 20-78 years, was imaged on a high resolution SD-OCT (Spectralis, Heidelberg Engineering). RNFL thickness was measured with undilated pupils, around the disc with 16 automatically averaged consecutive circular B-scans (3.4 mm diameter, 768 A-scans) and using an online tracking system to compensate for eye movements. The thickness of RNFL was automatically segmented using the Spectralis software. RNFL thickness was then averaged to 32 sectors (11.25° each) and 4 quadrants (Fig.1), respectively. One randomly selected eye of each patient entered the study.

Results: : Average RNFL thickness in the study population was 97.2±9.7µm (95% CI 95.7-98.7µm). The RNFL was thickest in the inferior quadrant (123.7±16.4µm), followed by the superior quadrant (117.9±14.5µm), the nasal and temporal quadrant. RNFL thicknesses of all 4 quadrants differed at the p<0.001 level. Average RNFL thickness had a significant negative correlation with age (r=-0.214, p=0.005), mean RNFL decrease per decade was 1.90 µm, (95% CI -3.4 to -0.37 µm). Therefore RNFL values were age-adjusted (Fig.2). Age-adjusted average RNFL thickness showed a significant correlation with axial length (r=-0.391, p=0.001) and with refractive error (r =0.396, p<0.001, analysis restricted to 164 phakic patients), but not with disc size (r=0.114, p=0.171).

Conclusions: : In accordance with the literature using other devices RNFL thickness measured with SD-OCT is significantly correlated with age and axial length. The age-adjusted values are supposed to be used for creating a normative database of SD-OCT in order to improve early diagnosis in glaucoma.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • nerve fiber layer • imaging/image analysis: clinical 
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