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G. Salcedo; Comparative Study of Corneal Endothelial Cell Changes in Pseudophaquic Patients Administered With Intracameral Vancomycin or Acetylcholine at the End of Surgery. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1149.
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To compare patients who underwent cataract surgery and who where administered with intracameral vancomycin, vancomycin and acetylcholine, or none, measured preoperatively and postoperatively with specular microscopy.
A statistical significant difference exists both in endothelial cell count and variance of patients who where administered the two drugs, versus patients with only vancomycin or no drug. This explains the presence of clinically greater corneal edema in such patients.
This study provides evidence that the use of a combination of acetylcholine and vancomycin at the end of cataract surgery is not recommended, although a prospective clinical trail is needed in order to prove the saftyness of both drugs.
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