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B. Xie, A. Dong, J. Shen, L. Lu, A. Rashid, T. YOSHIDA, S. Hackett, P. Campochiaro; Id1 Deficiency Suppresses Ocular Neovascularization. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1179.
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Inhibitor of differentiation (Id) proteins are dominant-negative helix-loop-helix (HLH) transcription factors primarily involved in regulating cellular differentiation. They have been implicated in tumor angiogenesis and in this study their affects in ocular neovascularization (NV) was investigated..
Expression of Id1 was investigated in mice with ischemic retinopathy and transgenic mice with expression of VEGF in photoreceptors. Mice deficient in Id1 were used to test the effect of Id1 in retinal and choroidal NV.
Mice deficient in Id1 showed a significant reduction in ischemia-induced retinal NV, choroidal NV at rupture sites in Bruch’s membrane, and VEGF-induced subretinal neovascularization. Mice lacking Id1 showed reduced levels of hypoxia-inducible factor-1alpha (HIF-1alpha) and suppression of ischemia-induced expression of VEGF and VEGF receptor 1.
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